摘要
目的:比较不同治疗方案对宫腔内人工授精(IUI)结局的影响,探讨较好的治疗方案以提高IUI的成功率。方法:回顾性分析了162例病人209个IUI治疗周期的治疗方案,根据病人用药情况分为3组:自然周期/IUI组、尿促卵泡素(hMG/IUI)组、克罗米芬(CC)+补佳乐/IUI组,比较各组病人在注射hCG日的子宫内膜厚度、卵泡发育情况、及妊娠结局等。结果:在162例病人中,有20例获得临床妊娠,临床妊娠率为12.34%,周期妊娠率为9.56%;3组病人的年龄、不孕年限,体重指数(BM I)及基础FSH、血清黄体生成素(LH)值、E2无差异;促排卵后,CC+补佳乐/IUI、hMG/IUI组病人的卵泡数高于自然周期组,子宫内膜厚度在自然周期组和hMG/IUI组明显高于CC+补佳乐/IUI组,有极显著性差异,P<0.01;妊娠结局3组分别为9、5、6。结论:IUI是治疗非输卵管因素不孕的一种有效方法,并且自然周期情况下,病人体内激素环境更接近于生理状况,能获得较好的妊娠结局。
Objective： To compare the results among different treatments of patients undergoing intrauterine insemination （IUI）. Methods： The retrospective data from 162 patients who underwent 209 cycles were analyzed. According to the drugs used, the patients were divided into three groups： nature cycle/IUI, menopausal gonadotropin （hMG） /IUI, clomiphene ciatrate （CC） ＋ Progynova/IUI. Criteria included endometrial thickness （Era）, follicle numbers, serum estradiol （ E2 ） levels on the human chorianic gonadotropin （hCG） administration day and clinical pregnancy. Results： There were 20 pregnancies, of which 18 pregnancies were ongoing~ Among three groups,the age, fertility age, body mass index, basic serum FSH, luteinizing hormone （ LH）, E2 had no difference （ P 〉 0. 05 ）. After ovulation induction, the follicular number on the hCG day has no difference between CC ＋ Progynova/IUI and hMG/IUI, comparing to those in nature cycles, both numbers increased. But Em both in nature cycle/IUI and hMG/IUI were significantly higher than that in CC ＋ Prog3;nova/IUI group （P 〈 0. 01 ）. The cIinic pregnancy were 9, 5, 6, respectively. Conclusion： The nature cycle gains better outcome, superior to ovulation.
出处
《中国妇幼保健》
CAS
北大核心
2006年第21期3008-3010,共3页
Maternal and Child Health Care of China
基金
南京市科技合作项目资助(200401060)
