1Czeizel AE,Dobo M,Vargha P.Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows a reduction in certain congenital abnormalities.Birth Defects Res A Clin Mol Teratol,2004,70:853-861
5Blom HJ,Shaw GM,den Heijer M,et al.Neural tube defects and fo-late:Case far from closed[J].Nat Rev Neurosci,2006,7(9):724-731.
6Amouzou EK,Chabi NW,Adjalla CE,et al.High prevalence of hy-perhomocysteinemia related to folate deficiency and the 677CT muta-tion of the gene encoding methylenetetrahydrofolate reductase incoastal West Africa[J].Am J Clin Nutr,2004,79(4):619-624.
7Wu M,Li J,Engleka KA,et al.Persistent expression of Pax3in theneural crest causes cleft palate and defective osteogenesis in mice[J].JClin Invest,2008,118(6):2076-2087.
8van der Linden IJ,Heil SG,den Heijer M,et al.The 894G>T variantin the endothelial nitric oxide synthase gene and spina bifida risk[J].JHum Genet,2007,52(6):516-520.
9Chan A,Robertson EF,Haan EA,et al.The sensitivity of ultrasoundand serum alpha-fetoprotein in population-based antenatal screeningfor neural tube defects.South Australia 1986-1991[J].Br J ObstetGynecol,1995,102(5):370-374.
10Ashwood ER.Evaluating health and maturation of the unborn:Therole of the clinical laboratory[J].Clin Chem,1992,38(8BPt 2):1523-1529.
