摘要
目的研究血栓通在脑缺血再灌注过程中对神经细胞的作用机理,特别是血栓通与细胞凋亡的关系。方法利用末端标记法,测定血栓通干预后脑缺血鼠脑组织中神经细胞的凋亡情况。结果血栓通能明显降低神经细胞凋亡百分率,降低凋亡神经细胞积分光密度,减轻病理损害。结论血栓通可显著抑制缺血再灌注诱导的脑神经细胞凋亡,起到一定程度的神经保护作用。
Objective To study the function mechanism of Xueshuantong on cerebral ischemic reperfusion and the relationship between Xueshuantong and apoptosis especially,Methods Using terminal deoxyfibo-nucleotide transferase-mediated dUTP-biotin nick end labeling （TUNEL） method, the changes of apoptosis cells in the rat＇s brain tissue on the cerebral ischemic reperfusion were determined after Xueshuantong intervention. Result Xueshuantong injection could reduce nerve cell apoptosis, the imegral optical density of the apoptotic neuron and decreased pathological damage significantly. Conclusions Xueshuantong injection can protect neuronal cell, markedly inhibit neuronal apoptosis induced by brain ischemia reperfusion injury.
出处
《广西医学》
CAS
2006年第9期1356-1358,共3页
Guangxi Medical Journal
关键词
血栓通
脑缺血再灌注损伤
神经细胞凋亡
Xueshuantong
Cerebral ischemia-repeffusion
Nerve cell apoptosis
