摘要
目的评价米安色林与丙咪嗪治疗抑郁症的临床疗效和安全性。方法将51例符合CCMD-3抑郁症诊断标准的抑郁症患者随机分为两组,分别给予米安色林和丙咪嗪治疗,于治疗前和治疗后1,2,4,6周末分别采用汉密尔顿抑郁量表(HAMD量表)、临床疗效总体评定量表及不良反应量表评定。结果米安色林与丙咪嗪总体疗效相似(P>0.05);米安色林组治疗第1周就起效;治疗前与治疗后比较,HAMD评分两组均有显著性差异(P<0.01),两组之间则无显著性差异(P>0.05),米安色林组的不良反应少于丙咪嗪组。结论米安色林是一种安全有效的新一代抗抑郁药物,适用于伴有失眠症状的老年抑郁症患者。
Objective To investigate the anti- depressive effect and adverse effects of mianserin and imipramine to treat depressive disorders. Methods 51 patients with depressive disorders according with the CCMD- 3 were enrolled. The examples were randomly divided into two groups treating respectively with mianserin and imipramine. Hamilton Rating Scale of Depression （HAMD）,Clinical Global Impression （CGI） and Treatment Emergent Symptom Scale （TESS） were used to evaluate the changes of clinical symptoms and side effects at baseline,one week, two weeks, four weeks and six weeks after treatment respectively. Results There were no significant differeces in CGI and HAMD scores between the two groups （P〉0.05）. Miansefin was quicker than imipramine in the anti-depressive effect and had less side effects than imipramine （P 〈0. 01 ）. Conclusion Mianserin is a new safe and effective anti- depressant.
出处
《中国药业》
CAS
2006年第16期52-53,共2页
China Pharmaceuticals
关键词
米安色林
丙咪嗪
抑郁症
临床疗效
mianserin
imipramine
depressive disorder
clinical therapeatic effect
