摘要
探讨多肽-Fe预防和治疗缺铁性贫血的效果及其口服的安全性。用自制的多肽-Fe治疗缺铁性贫血大鼠,铁的剂量为:40mg/kg·d;并用小鼠做急性毒性试验和长期服用试验,与NaFeEDTA治疗组及单纯给水组比较。治疗前后各组大鼠血红蛋白变化依次为77.1→105.4,77.4→92.6,77.4→78.6;观察7d未见小鼠急性毒性反应;用药3月后对90只小鼠进行观察,组织活检、石蜡切片均未见明显异常。多肽-Fe抗贫血效果优于NaFeEDTA;作为铁营养强化剂长期口服安全,无明显毒副作用。
This paper studies the effect and safety of polypeptide-Fe, as a fortified-Fe, in preventing and treating iron-deficiency anemia. Iron-deficiency anemia rats were treated with polypeptide-Fe, compared with the NaFeEDTA and the deionized water as control. The dosage of iron is 40 mg· kg^-1· d^-1. The changes of hemoglobin were 77.1→105.4,77.4→92.6,77.4→78.6, respectively. There were no adverse effects observed on a 7-days acute toxicity test. No abnormalities were found in autopsy and paraffin section. The effect of polypeptide-Fe was more satisfactory than that of NaFeEDTA in preventing and curing iron-deficiency anemia and no adverse effect was found in polypeptide-Fe.
出处
《食品研究与开发》
CAS
北大核心
2006年第7期179-181,共3页
Food Research and Development
基金
天津科技大学自然科学基金项目(20030216)
