摘要
目的:研究龙胆泻肝汤对四氯化碳(CC l4)所致急性肝损伤大鼠的靛氰绿(ICG)肝清除率的影响。方法:将32只大鼠随机分为空白对照组、模型组和龙胆泻肝汤高、低剂量组,每组8只。用CC l4制作大鼠急性肝损伤模型,测定下列变化:(1)大鼠血清天冬氨酸转氨酶(ALT)、丙氨酸转氨酶(AST);(2)肝脏形态学的改变;(3)肝血流量和靛氰绿肝清除率的改变;观察龙胆泻肝汤对CC l4大鼠急性肝损伤的影响。结果:龙胆泻肝汤能明显抑制CC l4所致大鼠血清中ALT及AST含量的升高(P<0.05或P<0.01),改善肝脏组织病理,对抗CC l4所致肝血流量和肝清除率下降(P<0.05)。结论:龙胆泻肝汤可保护肝脏,对抗CC l4所致肝清除率和肝血流量下降。
Objective ： To study the influence of Longdanxiegan on the hepatobiliary transportation in rats treated by carbon tetrachloride （ CC14 ）. Methods ： 32 rats were randomly allocated to normal control group, model group and Longdanxiegan groups （low - and high - dosage ）. The following studies were carried out： （ 1 ） Determination of the serum levels of aspartate transaminase （AST） and alanine transaminase （ ALT ） ; （ 2 ） Observation of the patho physiological changes and （3） Determination of hepatic plasma flow and ICG hepatic clearance by a continuous indocyanine green （ICG） infusion method. Results ：Longdanxiegan significantly reduced acute liver injury induced by CC14, decreased ALT and AST in serum （ P 〈 0.05 or P 〈 0.01 ） , improved the pathophysiologica]. changes, antagonised the decreses in the hepatic plasma flow and hepatic clearance of ICG in CC14 - treated rats （ P 〈 0.05 or P 〈 0.01 ）. Conclusion ： Longdanxiegan has protecting effects for the acute hepatic injury induced by CC14, antagonise CCla - induced decreses in the hepatic plasma flow and hepatic clearance of ICG.
出处
《辽宁中医杂志》
CAS
北大核心
2006年第8期1041-1042,共2页
Liaoning Journal of Traditional Chinese Medicine
基金
河北省科技厅科研课题(06276166)
关键词
龙胆泻肝汤
四氯化碳
靛氰绿
肝清除率
Longdanxiegan
carbon tetrachloride
indocyanine green
hepatobiliary transport
作者简介
石红（1960-），男，河北石家庄人，副主任药师，学士，从事药剂学工作。
