摘要
目的探讨P53蛋白在卵巢上皮肿瘤组织中的表达及意义。方法应用免疫组织化学方法分别检测83例卵巢上皮肿瘤病人P53蛋白的表达,分析其与病理类型、细胞分化程度及临床分期的关系。结果卵巢上皮肿瘤恶性组P53蛋白阳性表达率明显高于交界组及良性组(χ2=3.857、21.776,P<0.01);恶性组中P53蛋白阳性表达率与组织类型无关(χ2=0.005,P>0.05);G1、G2级阳性表达率显著低于G3级(χ2=5.154、7.540,P<0.05);临床Ⅰ、Ⅱ期阳性表达率低于Ⅲ、Ⅳ期(χ2=5.236,P<0.05);P53蛋白阳性病人5年生存率显著低于P53蛋白阴性的病人(χ2=4.919,P<0.05)。结论P53蛋白表达的检测对卵巢上皮肿瘤良、恶性的鉴别及卵巢上皮性癌预后的评估有一定的意义。
Objective To investigate the significance of protein P53 expression in the ovarian epithelial tumor. Methods Immunohistochemical method was applied to detect theP53 expression in 83 patients ovarian epithelial tumor. The relationship of P53 expression with pathological type, cell differentiation, and clinical staging was analyzed. Results P53 expression in malignant group was significantly higher than those in borderline and in benign group （x^2=3.857.21.776; P〈0.01）. TheP53 expression in malignant group was irrelevant to histological type （x^2 =0. 005, P〉0.05）; it was evidently less expressed in G2 and G2 groups than in G3, group （x^2=5. 154.7. 540,P〈0. 05 ）, its expression in stages Ⅰ and Ⅱ was less than that of stages Ⅲ and Ⅳ （x^=5.236,P〈0.05）. The 5-yearsurvival rate in patients with P53 positive was less than those with P53 negative （x^2= 4. 919, P〈0.05）. Conclusion The detection of P53 expression is of certain significance in differential diagnosis between malignant and nonmalignant epithelial ovarian tumor, and in assessment of the prognosis of ovarian carcinoma.
出处
《青岛大学医学院学报》
CAS
2006年第3期255-256,共2页
Acta Academiae Medicinae Qingdao Universitatis
作者简介
王雪鹤（1975-），女，在读硕士
