摘要
用不同剂量网状内皮增生症病毒(REV)感染肉鸡和SPF鸡后,检测血液中T淋巴细胞对ConA的反应和NK细胞、细胞毒T细胞(CTL)的细胞毒性作用以及NDV抗体生成变化等,观察REV感染对机体非特异性、特异性细胞免疫反应和体液免疫反应的影响。结果表明无论高剂量还是低剂量REV感染均造成体液免疫和非特异性细胞免疫抑制,而且高剂量比低剂量对免疫功能的抑制作用更强,但对NK细胞和细胞毒T细胞的细胞杀伤活性却有升高趋势,在抗肿瘤方面发挥一定的作用。这种结果说明REV感染对机体的免疫抑制是有选择性的,且抑制程度与感染病毒量有关。
To access the effect of different infective dose of REV on the specific and non-specific immune in chickens, immune responses of T lymphocytes to ConA, cytotoxic activity of natural killer cells and cytotoxic T lymphocytes（CTL）and humoral immunity response to NDV vaccine were detected in broilers and specific-pathogen-free chickens infected with different dose of REV. The results showed that REV infection, not only at higher dose but at low dose, could cause the immunosuppression of humoral and cellular immune in chickens, which was related to the infective dose of REV. But the cytotoxic activities of NK cell and CTL were enhanced in chickens infected with REV. It could be concluded that REV infection appeared to depress certain immune response but not all the immune responses.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2006年第9期893-898,共6页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金重点项目(30330450)
作者简介
郭慧君（1972-），男，山东东平人，博士生，讲师，主要从事病毒免疫学和营养生理学研究。
