摘要
单纯疱疹病毒是引起单纯疱疹和生殖器疱疹的主要病原体。近年来关于单纯疱疹病毒的耐药时有报道。大量研究证明,胸苷激酶和DNA聚合酶缺陷是导致单纯疱疹病毒耐药的主要机制。就近年来对HSV耐药的相关研究初步探讨单纯疱疹病毒耐药的流行趋势及其耐药机制。
HSV is the major pathogen of herpes simplex and genital herpes. The increasing prevalence of GH has had a profound effect on the health of human beings in the world. The emergence of more and more drug-resistant HSV strains is associated with the widespread and frequent use of antiviral drugs in the treatment, suppressive therapy and prophylaxis of HSV infection, and with increasing of HIV infection. More and more drug-resistant HSV strains have been reported recently. The mutations in thymidine kinase and DNA polymerase genes are proved to be the main mechanism of drug-resistance. This review discusses the prevalence and mechanism of HSV drug-resistance.
出处
《国际皮肤性病学杂志》
2006年第5期318-320,共3页
International Journal of Dermatology and Venereology
