摘要
为了研究替普瑞酮对胃溃疡的治疗效果，对１０６例经胃镜证实的胃溃疡病人，随机分为Ａ组（替普瑞酮＋西咪替丁）和Ｂ组（单用西咪替丁）。４周溃疡愈合率Ａ、Ｂ两组分别为７２．４％和５２．１％（Ｐ＜０．０５），８周为９３．１％和８９．６％（Ｐ＞０．０５）；Ｓ２期的获得率４周分别为３４．５％和１０．４％，８周为５０．０％和２０．８％（Ｐ＜０．００５）。氨基己糖测定：Ａ组治疗后（１７．７９±２．００μｇ／ｍｇ）明显高于治疗前（１４．２７±２．４７μｇ／ｍｇ）（Ｐ＜０．０５），而Ｂ组治疗前后则无明显变化。本研究结果强烈提示Ａ组加用替普瑞酮不仅加速了胃溃疡的愈合，而且显示溃疡愈合质量亦明显高于单用西咪替丁组。
Onehundredandsixpatientswithactivegastriculcerprovenbyendoscopywereran-domlyalocatedtoreceivecimetidine800mgatbedtime+teprenone50mgthricedaily;orcimetidine800mgatbedtimealoneinatrialcomparingtheulcerhealingrateandthequalityofhealingat4or8weeks.At4weeks72.4%(42/58)ofthoseoncimetidine+teprenoneand52.1%(25/48)oncimeti-dinealonehadulcershealedincomparisonof93.1%(54/58)and89.6%(43/48)respectivelyat8weeks.Thedifferencewassignificantat4weeks,indicatingtheulcerhealmorerapidlyinthecombina-tiontherapygroup.ThestageS2achievementrateswere34.5%(20/58)and10.4%(5/48)at4weeks(P<0.05),50.0%(29/58)and20.8%(10/48)at8weeks(P<0.05)respectively,indicatingthequalityofulcerhealingwasmuchbeterinthecombinationtherapygroup.Thegastricmucosalhex-osaminelevelsincreasesignificantlyaftertreatment(17.79±2.00μg/mg)ascomparedtothatbeforetreatment(14.27±2.47μg/mg)inthecombinationtherapygroup,indicatingthatteprenonestimulatesmacromolecularglycoproteinsynthesisingastricmucosa.Thisisthoughttobeasignificantfactorinthehealingprocessofgastriculceration.Conclusion:Itisreasonabletoadministerteprenone,anagentincreasingmucosalresistance,concurrentlywithH2blockersinthetreatmentofactivegastriculcers.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1996年第12期807-809,共3页
Chinese Journal of Internal Medicine
