摘要
目的探讨四联疗法对消化性溃疡的治疗作用及根除幽门螺杆菌的效果。方法将102例胃镜证实为消化性溃疡者随机分为3组,A组48例给予三九胃泰2.5g+雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg,bid;B组31例给予铋剂220mg+雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg,bid;对照组(C组,23例)给予雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg,bid;以上药物除抗菌药物只服用2周外,其余药物服至6周末疗程结束,第7周复查胃镜和/或13C呼气试验。结果溃疡总愈合率A组、B组、C组分别为90.9%、100%、86.4%,S2获得率分别为68.2%、73.1%和45.5%,Hp根除率分别为73.3%,76.1%和52.6%,症状缓解率大致相似,3组均无明显不良反应发生。结论雷尼替丁三联疗法加用铋剂和三九胃泰均可使S2获得率增加,同时Hp根除率上升,临床观察无明显不良反应。
Objective To study the efficacies of quadruple regim ens for the treatm ent of peptic ulcer disease anderadication of H elicobacter pylori(H p). M ethods 102 patients w ith H p associated peptic ulcer w ere random ly divid-ed into three groups, group A(n=98) received sanjiuw eitai-based quadruple regim en(sanjiuw eitai 2.5g,bid+ranitidine150m g,bid+am oxicilillin 500m g,bid+m etro nidazole400m g,bid);group B (n=31) received colloidal bism uth subcitrate(Livzon)110m g,bid+ranitidine 150m g,bid+am oxicillin 500m g,bid+m etronidazole 400m g,bid.group C (n=23) receivedranitidine 150m g,bid+am oxicillin 500m g,bid+m etronidazole 400m g,dib.Antibiotics w ere given for tw o w eeks, the oth-er drugs w ere given for six w eeks, the efficacies w ere determ ined by gastroendoscopy or13C -U BT. Results Theulcer healing rate w ere 90.9% ,100% ,86.4% in group A,B,C respectively; the stage S2 achievem ent rate w ere68.2% ,73.1% and 45.5% ;the eradication rate of H p w ere in three 76.1% ,73.3% and 52.6% ,the sym ptom s w ere re-m issive sim ilarly in three groups, there w ere no side effects in three groups. Conclusion Ranitidine-based tripleregim ent plus Livzon or Sanjiuw eitai can raise the stage S2achievem ent rate and H p eradication rate. Three w asno side effect.
