摘要
冷和细胞凋亡有着密切的关系,冷诱导细胞凋亡的研究已经成为器官移植医学领域里的热点。冷诱导细胞凋亡的信号转导过程错综复杂,细胞内活性氧自由基、Ca2+、Fe2+以及冷相关基因都介导或调控冷引起的细胞凋亡。结合有关冷和细胞凋亡方面的研究进展,综述了与冷引起的细胞凋亡相关的信号转导过程和相关基因的调控机制。
Cold and apoptosis are tightly correlated and the research on cold-induced apoptosis has become a hotspot within the transplantation medicine area. The signal transduction involved in the cold-induced apoptosis is anfractuous, either mediated or modulated by reactive oxygen species （ROS）, Ca^2＋, Fe^2＋ and cold-relevant genes in vivo. Based on the worldwide research progress, we try to generally summarize the signal transduction and modulation mechanism involved in the course of cold-induced apoptosis.
出处
《细胞生物学杂志》
CSCD
2006年第4期551-555,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金资助项目(No.30370876)~~
关键词
冷
细胞凋亡
活性氧
调控
信号转导
cold
apoptosis
reactive oxygen species
modulation
signal transduction
作者简介
通讯作者。Tel：0571—88206536，Fax：0571—88206535，E-mail：myzhu@zju．edu．cn
