摘要
研究壳寡糖抗肿瘤的作用和免疫调节作用.应用SRB法对壳寡糖进行体外抗肿瘤作用研究,对S180荷瘤小鼠的瘤重和胸腺及脾指数进行了的观察,同时观察了壳寡糖体外对小鼠腹腔巨噬细胞吞噬中性红能力的影响.壳寡糖体外对肿瘤生长的抑制作用不明显,体内实验表明壳寡糖能抑制S180小鼠的瘤重.壳寡糖能显著提高荷瘤小鼠的胸腺指数和脾指数.壳寡糖体外实验能提高小鼠腹腔巨噬细胞吞噬中性红的能力.提示壳寡糖有可能是通过调节荷瘤小鼠免疫力实现抗肿瘤作用的.
To study the antitumor activities of chitooligosaccharidean and its action on mouse peritoneal macrophages. The in vitro antitumor action was observe by SRB . In vivo its effects were studied by observeing tumor weight of mouse S180, thymus, spleen exponential, tuluylene red pinocytic test of mouse peritoneal macrophages. The effects of chitooligosaccharide inhibits the growth of S180 tumor cell is not in evidence in vitro,but it can cary iout n vivo. Chitooligosaccharide promoted the pinocytic ability of mouse peritoneal macrophages in vitro. The results showed that antitumor activities of chitooligosaccharide may be achieved by immunity regulation.
出处
《哈尔滨商业大学学报（自然科学版）》
CAS
2006年第4期8-10,共3页
Journal of Harbin University of Commerce：Natural Sciences Edition
基金
黑龙江省青年基金(NoQC04C36)
关键词
壳寡糖
抗肿瘤作用
SRB法
巨噬细胞
chitooligosaccharide
antitumor activity
SRB
peritoneal macrophages
作者简介
曹秀明（1964-）,女,副研究员,博士,研究方向：中药抗肿瘤药物.
