摘要
目的:分析川芎嗪对溃疡性结肠炎的干预效果及作用途径。资料来源:应用计算机检索Pubmed1990-01/2006-02有关川芎嗪治疗溃疡性结肠炎的文献,检索词“Ulcerativecolitis,tetramethypyrazine”,限定文章语言种类为English。同时应用计算机检索维普中文期刊数据库1999-01/2005-12有关川芎嗪治疗溃疡性结肠炎的文献,检索词“溃疡性结肠炎,川芎嗪”,限定文章语言种类为中文。资料选择:对检索到的川芎嗪对溃疡性结肠炎作用方面的相关信息进行整理,选取针对性强的文章,同一领域的文献则选择近期发表或权威杂志的文章。资料提炼:共检索到30篇相关文献,其中17篇文章符合要求。资料综合:川芎嗪能抗炎症介质,清除自由基;保护血管内皮细胞,改善微循环;抗黏附分子等,具有较强的抗氧化和改善免疫功能等药理作用,因此有可能从清除自由基、抑制肠道炎症反应以及改善微循环功能等多方面来治疗溃疡性结肠炎,有望成为一种具有积极治疗作用、低副作用及良好应用开发前景的药物。结论:川芎嗪通过清除自由基、抑制肠道炎症反应以及改善微循环功能等多方面作用途径在理论上为治疗溃疡性结肠炎提供了可能,但该类药物更为精细的治疗靶点都有待于进一步探索。
OBJECTIVE：To analyze the interventional effect and pathway of ligustrazine for treating ulcerative colitis （UC）.
DATA SOURCES：An online search was undertaken in Pubmed between January 1990 and February 2006 to identify the articles concerning ligustrazine therapy of UC using the key words of ＂Ulcerative colitis, tetramethypyrazine＂ and language was limited to English. Meanwhile, the Chinese articles about ligustrazine therapy of UC were retrieved at Weipu Chinese Journals Database from January 1999 to December 2005 by imputing key words of ＂ulcerative colitis, ligustrazine＂.
STUDY SELECTION：All the data related to the treatment of ligustrazine for UC were arranged, and those aimed directly at the subject were chosen. Articles published on authority magazines or published recently were preferred.
DATA EXTRACTION：Totally 30 articles were probed into, and 17 ones met the criteria.
DATA SYNTHESIS：Ligustrazine is effective for anti-inflammation media, cleaning free radical, protecting vascular endothelial cells, improving microcirculation and anti-adhesive molecule, etc. It has strong functions of resisting oxidizations and improving immune systems, which can cure UC from multi-ways such as cleaning free radical, inhibiting inflammatory reaction in intestinal tract and improving microcirculation. It is hopeful to take ligustrazine as a medicine with good effects, good market potential and low side effect.
CONCLUSION：Thcoretically, ligustrazine is a potential therapy of UC by removing free radical, improving microcirculation and depressing inflammatory reaction, etc. although more detailed curing targets of such medicine need to be further probed.
出处
《中国临床康复》
CSCD
北大核心
2006年第27期122-124,共3页
Chinese Journal of Clinical Rehabilitation
作者简介
江琼，女，1964年生，重庆市人，汉族，重庆医科大学在读硕士，副教授，主要从事消化内科方面的研究。
