摘要
目的:探讨VEGFC、VEGFD在乳腺癌组织中的表达及其作用。方法:采用免疫组织化学方法对112例乳腺癌组织切片染色,观察乳腺癌组织中VEGFC,VEGFD以及LYVE1的表达情况。结果:112例乳腺癌组织中,VEGFC阳性率为83.0%,VEGFD阳性率为75.9%。二者表达呈正相关(r=0.767,P<0.001)。VEGFC阳性指数在淋巴结转移组(60.54±16.73)明显高于未转移组(43.56±15.64)(P<0.05)。VEGFD阳性指数在淋巴结转移组(60.42±16.26)明显高于未转移组(41.82±15.93)(P<0.05)。随着癌细胞VEGFC和VEGFD表达强度增强,LYVE1阳性淋巴管数也随之增加,各组间均有显著性差异(P<0.001)。VEGFC和VEGFD的表达与LYVE1阳性淋巴管均呈一定相关性,(前者r=0.864,P<0.001;后者r=0.870,P<0.001)。乳腺癌中LYVE1阳性淋巴管数在淋巴结转移组(13.72±7.74)明显高于未转移组(7.69±5.85)。结论:VEGFC及VEGFD在人乳腺癌组织呈高水平表达,表达强度与肿瘤间质淋巴管密度及肿瘤淋巴结转移有关;肿瘤间质淋巴管密度与肿瘤淋巴结转移密切相关。
Objective：To identify the expressions of vascular endothelial growth factor （VEGF）-C and VEGF-D in primary breast cancer and their significance. Methods：A series of 112 primary breast cancer specimens were detected for the expressions of VEGF-C,VEGF-D as well as lymphatic vessel endothelial hyaluronan receptor （LYVE）-1 by immunohistochemical method. Results：Among 112 cases of breast cancer, the positive rates of VEGF-C and VEGF-D were 83.0% （93/112） and 75.9% （85/ 112）, respectively. The expression of VEGF-C and VEGF-D had positive correlation （r=0. 767 ,P〈0. 001）. The positive index of VEGF-C and VEGF-D in breast cancer with lymph node metastasis was significantly higher than that with no lymph node metastasis[（60.54±16.73） vs （43.56±15.64）,P〈0.05; （60.42±16.26） vs （41.82±15.93）,P〈0.05]. With the increase in the expression of VEGF-C or VEGF-D, the number of LYVE-1 positive vessels also increased. There was significant difference between each group（P〈0. 001）. Expression of VEGF-C or VEGF-D was correlated with the number of LYVE-1 positive vessels,respectively （r=0. 864,P〈0. 001;r=0. 870, P〈0. 001）. The number of LYVE-1 positive vessels in breast cancer with lymph node metastasis was significantly higher than that without lymph node metastasis [ （ 13. 72 ± 7. 74） vs （ 7. 69 ± 5. 85 ）]. Conclusion：VEGF-C and VEGF-D are over expressed in primary breast cancer. Their expressions are related to the number of LYVE-1 positive vessels and lymph node metastasis. The number of LYVE-1 positive vessels is closely related to lymph node metastasis.
出处
《肿瘤》
CAS
CSCD
北大核心
2006年第6期551-554,共4页
Tumor
基金
广东省自然科学基金项目(编号:011044)
广东省医学科研基金项目(编号:A2002252)
广州市科技计划项目(编号:医学B类6号)
关键词
乳腺肿瘤
血管内皮生长因子C
血管内皮生长因子D
血管内皮生长因子受体-3
内皮
淋巴管
Breast neoplasms
Vascular endothelial growth factor C
Vascular endothelial growth factor D
Vascular endothelial growth factor receptor-3
Endothelium,lymphatic
作者简介
汤红平（1978-），男（汉族），硕士研究生Corresponding author. Tel ： 020-81340340 E-mail ： thp197807@ 126. com
