摘要
蛇床子素（Ｏｓｔ）对氯仿诱发的小鼠室颤、氯化钙诱发的大鼠室颤均有明显的预防作用，对乌头碱诱发的大鼠心律失常有明显的治疗效果，且能明显提高兔心室电致颤阈．这些结果均表明Ｏｓｔ有抗心律失常作用，并揭示其对钠、钙通道有一定的阻断作用。
Osthol (Ost ) was not only effective in preventing ventricular fiarillation indu-ed by chloroform in mice and by calcium chloride in rats, but was effective in treating arrh-ythmia illduced by aconitine in rats. Furthermore, Ost raised the threshold of ventricular fibrillution induced by electrical stimulation in rabits. These results indicated that Ost exhibitedunit-arrhythmia effects by blocking Na+, Ca2+ channels to a certain extent.
