摘要
目的观察比较四君子汤、右归饮对衰老模型大鼠学习记忆能力和脑组织中自由基的影响。方法以D-半乳糖腹腔注射致亚急性衰老动物模型,观察大鼠水迷宫游泳到达出口的时间及错误次数及脑组织中SOD、MDA、NO、NOS等有关自由基指标。结果四君子汤可缩短衰老模型大鼠水迷宫游泳到达出口的时间;右归饮可升高衰老模型大鼠脑组织SOD水平,降低MDA水平,四君子汤可降低衰老模型大鼠脑组织中NO、NOS水平。结论四君子汤可改善D-半乳糖致衰老模型大鼠空间学习记忆能力,具有增强记忆的功能;右归饮能减轻模型大鼠脑组织自由基对机体的损伤,具有良好的抗自由基作用。
Objective To compare the effect of Sijunzi Tang and Yougui Yin on learning - memory ability and free radicals in aging rat model. Methods The aging rat model was induced by intraperitoneal injection of D - galactose. The swimming time and error times in water maze test were observed and the free radicals SOD, MDA, NO, NOS in rat brain tissue were measured. Results Sijunzi Tang could shorten the rat swimming time in water maze test. Yougui Yin could increase SOD level and decrease MDA level in brain tissue of model rat, while Sijunzi Tang could decrease NO and NOS level. Conclusion Sijunzi Tang could improve the rat spatial learning and memory ability, and Yougui Yin could relieve the damage of free radical in brain tissue of the aging rat model.
出处
《中药新药与临床药理》
CAS
CSCD
2006年第3期164-167,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广东省教育厅自然科学基金(Z03015)
广东省自然科学基金(0401226)
关键词
四君子汤
右归饮
衰老
记忆能力
自由基
Sijunzi Tang
Yougui Yin
Aging
Memory ability
Free radicals
作者简介
刘梅（1975-），男，助理研究员，从事证候理论实质的研究。
