摘要
【目的】观察强心方对超容量负荷型心衰模型兔的治疗作用。【方法】新西兰雄性兔20只,随机分为4组:模型组、强心方组(中药组,2.6 g/kg)、西药组(20μg/kg地高辛+1 mg/kg速尿片)、中西药组(2.6 g/kg强心方+20μg/kg地高辛+1 mg/kg速尿片);复制超容量负荷型心衰模型,造模后6 h各给药组分别按设计剂量灌胃给药,连续7 d;采用四道生理仪记录并计算心率(HR)、主动脉收缩压(SBP)、主动脉舒张压(DBP)、左心室收缩压(LVSP)、左心室舒张压(LVPP)、左室内压最大上升速率(+dp/dtmax)、左室内压最大下降速率(-dp/dtmax),左室内压最大变化速率(±dp/dtmax)的值,并采血检测血清超氧化物歧化酶(SOD)和丙二醛(MDA)的含量。【结果】造模后各组体质量无显著性差异,给药1周后西药组体质量显著下降(P<0.05);造模后各组心率下降(与造模前比较,P<0.05或P<0.01),给药1周后各给药组心率与模型组比较无显著性差异;给药1周后各给药组对SBP、DBP、LVDP值无明显影响,中西药组可使LVSP值升高(P<0.01);给药后各组+dp/dtmax、-dp/dtmax、±dp/dtmax值均升高(与模型组比较,P<0.05或P<0.01);模型组血清SOD水平降低,MDA水平升高(均P<0.01),各给药组均可升高SOD水平,降低MDA水平(P<0.05或P<0.01)。【结论】强心方对超容量负荷型心衰模型兔具有一定的治疗作用,与强心、利尿西药合用可减轻其副作用。
[Objective] To investigate the therapeutic effect of Qiangxin Prescription （QP） on rabbits with heart failure induced by volume overload. [ Methods ] Twenty New Zealand male rabbits were randomized into four groups： the control group, QP group （QP 2.6 g/kg）, western medicine group （Digoxin 20 μg/kg and furosemide lmg/kg） and QP ＋ western medicine group （QP 2.6 g/kg, Digoxin 20 μg/kg and furosemide 1 mg/kg）. Rabbit models with heart failure induced by volume overload were established. Six hours after the modeling, the treatment groups were given the corresponding drugs according to the experimental design, the treatment lasting 7 days. Four-channel physiologic instrument was used to examine the heart rate （HR）, aortic systolic blood pressure （SBP）, aortic diastolic blood pressure （DBP）, left ventricular systolic pressure （LVSP）, left ventricular diastolic pressure （LVDP）, the maximum rate of left ventricular pressure rise （ ＋ dp/dtmax）, the maximum rate of left ventricular pressure decrease （ - dp/dtmax） and the maximum rate of left ventricular pressure change （ ± dp/dtmax）. Meanwhile, the serum contents of superoxide dismustase （SOD） and malondialdehyde （MDA） were detected. [Results] The difference was insignificant in the body weight in different groups after the modeling but the body weight in western medicine group was decreased one week after medication （ P 〈 0.05 compared with the control group）. HR decreased in the four groups after the modeling （ P 〈 0.05 or P 〈 0.01 compared with that before modeling） and HR in the treatment groups did not differ from that in the model group one week after medication. SBP, DBP, LVSP and LVDP decreased in the four groups after the modeling （P 〈 0.05 or P 〈 0.01 compared with those before the modeling）, no obvious changes of SBP, DBP and LVDP were found in the treatment groups but LVSP increased in QP ＋ western medicine group one week after medication （ P 〈 0.01 compared with the control group）. ＋ dp/dtmax, - dp/dtmax, ± dp/dtmax decreased in the four groups after the modeling （P 〈 0.01 compared with those before the modeling） and then were increased in the treatment groups one week after medication （ P 〈 0.05 or P 〈 0.01 compared with the model group）. SOD content decreased and MDA increased in the model group, and SOD content increased and MDA decreased in the treatment groups after treatment （ P 〈 0.05 or P 〈 0.01 compared with the model group）. [Conclusion] QP exerts an therapeutic effect on rabbits with heart failure induced by volume overload, and QP can reduce the side effects when used in combination with cardiotonic and diuretic.
出处
《广州中医药大学学报》
CAS
2006年第3期241-244,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
强心方/药理学
心力衰竭
充血性/中药疗法
疾病模型
动物
兔
QIANGXIN PRESCRIPTION/pharmacology
HEART FAILURE, CONGESTIVE/TCD therapy
DISEASE MODELS, ANIMAL
RABBITS
作者简介
王萧（1972-），男，副研究员
