摘要
目的:观察苗药及中药配伍对COPD大鼠模型中TGF-β1水平的拮抗。方法:用熏香烟并复合木瓜蛋白酶雾化吸入法复制大鼠COPD模型,以ELISA法检测BALF中TGF-β1含量,并观察支气管管壁局部病理变化。结果:治疗后支气管管壁纤维组织和平滑肌增生有所改善;模型组BALF中TGF-1β较正常对照组明显升高(P<0.001);苗药加补气活血药组BALF中TGF-1β较其他治疗组均降低(P<0.05)。结论:苗药加补气活血组能降低TGF-β1水平,并且能修复和缓解COPD模型的病理改变。
Objective：To observe Miao Nationality＇s Herb and Chinese medicine adjust the changes of TGF-β1 level in the COPD rat models. Methods：The COPD rat model was established by exposure to cigarette smoking and inhalation of Papain Coarse-enzyme. The TGF-β1 in the BALF measured by ELISA. Observing the change of pathology of btonchiolar walls partly. Results： The fibrous tissue and smooth muscle in the bronchiolar walls have been inproved to some degree after treatment. The TGF-β1 in the COPD rat model group were higher than those of normal group（ P 〈 0.001 ）. The TGF-β1 in the Miao Nationality＇s take a tonic to vital energy and invigorate the circulation of blood group were lower than other treatment of groups （ P 〈 0. 05 ）. Conclusions： Miao Nationality＇s take a tonic to vital energy and invigorate the circulation of blood group can reduce the TGF-β1 level and restore the change of pathology.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2006年第4期289-291,共3页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
COPD
止咳化痰苗药
转化生长因子Β1
大鼠模型
Chronic Obstructive Pulmonary Disease （COPD）
Miao Nationality＇s relieves cough andreduced phlegm herb
Transforming growth factor-β1 （TGF-β1）
作者简介
葛正行（1962-），男（布依族），贵州人．副主任医师，医学学士，从事中西医结合治疗呼吸系统疾病临床及实验研究。
