摘要
目的:观察4例乳腺浸润性微乳头状癌(IMPC)的临床病理学特点,结合文献探讨乳腺浸润性微乳头状癌的病理形态学特征、诊断、鉴别诊断及免疫组化特点和预后.方法:采用光镜和免疫组化SP法对4例IMPC进行观察并结合文献分析.结果:4例乳腺IMPC与浸润性导管癌相比无特殊的临床症状、体征及大体检查.光镜下特征性表现为肿瘤细胞呈桑椹状、微乳头状或小腺管样排列,癌巢与周围间质形成明显的空隙.微乳头缺乏纤维血管轴心.免疫组化染色EMA阳性部位在癌细胞巢团或微乳头状、腺管的外表面.结论:浸润性微乳头状癌是一种少见类型的浸润性乳腺癌,具有淋巴管侵袭性强、淋巴结转移率高、预后差的生物学行为.
AIM： To observe the clinical and pathological characteristics of 4 cases with invasive micropapillary carcinoma （IMPC） of the breast and in combination with literatures to explore the pathomorphological features, diagnosis, differential diagnosis, immunohistochemical features and prognosis of IMPC. METHODS： Immunohistochemical SP method and light microscopy were adopted to make an observation and analysis for the 4 IMPC cases based on literatures. RESULTS ： Compared with infiltrating ductal carcinoma,the 4 IMPC cases were not significantly different in clinical symptoms, signs and general check-up. What was observed under a light microscope included： tumor cells were mulberry- and micropapillary-shaped or it was of glandule tubular arrangement; there was obvious interspace between cancer nest and neighboring areas; micropapillary was empty of fiber blood vessel axes; immunohistochemical staining showed EMA positive location was both at outward surface of glandule duct and at micropapillary-like cancer nest. CONCLUSION： IMPC is a kind of rare invasive breast cancer with such biologic behaviors as a strong attacking on lymphatic and high probability of lymph node transfer and poor prognosis.
出处
《第四军医大学学报》
CAS
北大核心
2006年第8期706-708,共3页
Journal of the Fourth Military Medical University
关键词
乳腺肿瘤
腺癌
乳头状
浸润癌
breast neoplasms
adenocarcinoma, papillary
invasive carcinoma
作者简介
张润岐，副教授．Tel：（029）88462772 Email：zhangmnqil957@163．com
