摘要
目的:探讨米非司酮对子宫内膜异位症(endometriosis,EMS)大鼠survivin表达的影响。方法:子宫内膜异位症大鼠随机分为正常对照组、低剂量和高剂量米非司酮组,灌胃4周后,分别取子宫内膜组织用免疫组化法测survivin的表达。结果:(1)各组在位内膜survivin的表达强度,高剂量组低于低剂量组(P<0.05)和正常对照组(P<0.05),而低剂量组和正常对照组间差异无显著性。(2)各组间异位内膜survivin的表达强度均有明显差异,高剂量组低于低剂量组(P<0.05)和正常对照组(P<0.01),低剂量组也明显低于正常对照组(P<0.01)。(3)不同组内在位、异位内膜survivin的表达强度,高剂量、低剂量组异位内膜均明显低于在位内膜(P<0.01),而正常对照组异位内膜则高于在位内膜(P<0.05)。结论:米非司酮治疗EMS可能与降低survivin的表达有关。
Objective To explore the effect of mifepfistone on expression of survivin in endometfiotic rats. Methods Endometriotic rats were randomly divided into control group and mifepristone group （including low-dose and high -dose groups）. 4 weeks after gastrogavage with tuwen-80 only （control group） or tuwen-80 plus mifepristone 0.62 mg/d （low -dose group） or 1.24 mg/d（high-dose group）, all of the rats were killed and tissues of ectopie and eutopie endometrium were removed for detecting survivin-expression via immunohlstochemistry （SP method）. Results （ 1 ） In the eutopic endometium, the expression intensity of survivin in the high-dose group was lower than that in the low-dose group and the control group （ P 〈 0. 05 ）. （2） In the ectopic endometium, the expression intensity of survivin in the high -dose group was lower than that in the low -dose group （ P 〈 0. 05 ） and the control group （ P 〈 0.01 ）. The expression intensity of survivin in the low dose group was lower than that in the control group （ P 〈 0.01 ） . （3） In both high -dose and low -dose groups, the expression intensity of survivin in the eetopic endometrium was lower than that in the eutopic endometfium （ P 〈 0. 01 ）, but in the control group, the expression intensity of survivin in the ectopic endometrium was higher than that in the eutopic endometrium （ P 〈 0.05 ）. Conclusion The treatment effect of mifepfistone on EMS might be related with decreased expression of survivin.
出处
《实用医学杂志》
CAS
2006年第5期510-512,共3页
The Journal of Practical Medicine
