摘要
目的观察甲基强的松龙冲击治疗儿童过敏性紫癜肾炎的临床疗效。方法分析30例行甲基强的松龙治疗的过敏性紫癜肾炎患儿的临床资料。结果经甲基强的松龙冲击治疗后,30例患儿中23例尿常规阴转或明显好转,总有效率达76·67%。在使其尿常规短期内阴转方面,轻型较重型、病程<3个月者较>3个月者显示了明显的优越性(P<0·05)。5例经皮肾穿刺术的患者,2例病理类型为IIb者对甲基强的松龙冲击治疗的效果较2例Ⅲb者好。在甲基强的松龙冲击治疗过程中,未见出现肾损伤加重现象及严重并发症发生。结论甲基强的松龙早期静脉冲击对儿童过敏性紫癜肾炎有一定治疗作用。
Objective To observe the treatment effect of methyl-prednisolone on children with Henoch-Schfinlein purpura nephritis. Methods A retrospective research was performed to analyze the clinical effect on 30 children with Henoch-Schfinlein purpura nephritis, whom were treated with methyl-prednisolone（ 15 -20 mg/kg eachtime, three times a course ）. Among them 5 cases underwent percutaneous renal biopsy before treatment. Results 23 patients showed recovery or obvious improvement in urine routine after the pulse therapy with methyl-prednisolone, and the total effective rate was 76. 67%. Concerning the short term of recovery in urine routine, light types or course of disease less than 3 months showed more superiority than severe types or course of disease excess of 3 months （P 〈 0. 05 ）. All renal biopsies were successful. Treated with methyl-prednisolone, 2 cases of the pathological class Ⅱb showed better efficacy than 2 cases of the pathological class Ⅲ b. No aggravation of renal lesions or serious complications were found. Conclusion with Henoch-Schfnlein purpura nephritis shows Early use of pulse therapy with methyl-prednisolone for children a surely therapeutical effect.
出处
《安徽医科大学学报》
CAS
北大核心
2006年第1期102-104,共3页
Acta Universitatis Medicinalis Anhui
基金
安徽省教育厅科研基金资助项目(编号:2001kj145)
作者简介
胡波，男，41岁，主任医师，副教授。
鹿玲，女，51岁，主任医师，教授，硕士生导师。
