摘要
目的探讨前列腺、膀胱及盆底肌伤害感觉神经在脊髓中枢的分布及其关系。方法用甲醛分别刺激S-D大鼠前列腺、膀胱、盆底浅层肌,用原位杂交方法确定脊髓中痛敏物质SP的分布及表达情况。结果甲醛刺激前列腺、膀胱及盆底肌引起相似(L6-S1)的脊髓节段内P物质的表达显著增强。结论接受前列腺、膀胱及盆底的伤害刺激的脊髓伤害感觉神经元有显著的互相重叠。前列腺、膀胱、盆底的病变可引起相似的疼痛感觉。
Objective To explore the distribution of the nociceptive neurons that received inputs from the prostate, bladder, and pelvic floor in the spinal cord. Methods Substance P expression within the dorsal horn of the spinal cord was determined by in situ hybridization after formalin irritation of the prostate, bladder, and superficial muscle of the pelvic floor. Results Formalin irritation of the prostate, bladder, and pelvic floor resulted in similar substance P expression within the dorsal horn of the spinal cord （ L6 to S1 ）. Conclusion There should be significant overlaps of nociceptive neurons within the spinal cord, which receive nociceptive inputs from the prostate, bladder, and pelvic floor. Pathological changes of the prostate, bladder, and pelvic floor could result in similar pain sensations.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2006年第2期157-159,共3页
Journal of Third Military Medical University
作者简介
周占松（1965-），男，河北省饶阳县人，硕士，副主任医师，副教授，主要从事前列腺炎及前列腺增生临床方面的研究，发表论文10余篇。电话：（023）68765341
通讯作者：宋波，电话：（023）68754186
