摘要
N-甲基-D-天冬氨酸受体(NMDA受体)是中枢神经系统中兴奋性递质谷氨酸受体的一种类型,属于离子型受体。它涉及了体内许多复杂的生理和病理过程,包括wind-up、中枢敏化、长时程增强、外周敏化和内脏疼痛、细胞坏死和凋亡,除此以外,还参与了痛觉过敏的产生和维持。对NMDA受体在痛觉过敏中作用的探讨为研发新一代的镇痛药提供了广阔的思路和前景。
NMDA receptors are a subtype of excitatory transmitters-glutamate receptor in the central nervous system. They belong to ionotropic receptors and play an important role in many complex physiological and pathological processes, including wind-up, central sensitization, long-term potentiation, peripheral sensitization, visceral pain, cellular necrosis and apoptosis, as well as induction and maintenance of the hyperalgesia. Study on effects of NMDA receptors on hyperalgesia provides a wide strategy and prosperity for a novel class of analgesics.
出处
《生命科学》
CSCD
2006年第1期51-54,共4页
Chinese Bulletin of Life Sciences
作者简介
陈菲（1980-），女，硕士研究生。
方步武（1962-），男，博士，副教授，博士生导师，通讯作者。
