摘要
目的观察心血管病患者血浆N端B型脑钠肽(NTproBNP)浓度的改变并探讨其临床意义。方法用ELISA法测定1112例心血管病患者及60名健康体检者血浆NTproBNP浓度并分析其与美国纽约心脏病协会(NYHA)心功能分级的关系。结果心血管病患者组血浆LogNTproBNP浓度[(3.01±0.36)fmol/ml]显著高于健康对照组[(2.65±0.10)fmol/ml]且方差分析显示不同的心血管病患者组间血浆NTproBNP浓度差异亦有统计学意义(F=45.147,P<0.001)。各心血管病组血浆NTproBNP浓度随着心力衰竭程度的加重(NYHA心功能分级升高)而显著上升(P<0.001);但同为1级心功能或同为2级心功能时,不同心血管病组间的血浆NTproBNP浓度差异有统计学意义(P<0.001或P=0.001)。多因素相关分析表明血浆NTproBNP浓度与NYHA心功能分级和年龄之间具有良好的正相关性(r=0.712,P<0.001及r=0.063,P<0.001)。结论心血管病患者血浆NTproBNP浓度随着心力衰竭严重程度的增加而升高,是评价心功能的敏感指标;在心功能改变早期,不同心血管疾病对血浆NTproBNP水平的升高可能给予不同的贡献。
Objective To study the relationship of plasma NT-pro Brain Natriuretic Peptide （NT- proBNP） levels with cardiovascular diseases. Methods Plasma NT-proBNP concentrations of patients with cardiovascular disease （n = 1 112） and of normal controls （n = 60） were measured by enzyme-linked immunosorbent＂ assay （ELISA）, and study the correlations of plasma NT-proBNP concentration with severity of heart failure, underling heart disease and New York Heart Association （NYHA） functional classifications in patients with cardiovascular disease. Results The plasma Log NT-proBNP concentrations of patients were significantly higher than those of the normal controls[ （3.01 ±0. 36 ） fmol/ml vs （2. 65 ±0. 10） fmol/ml, P 〈 0. 001 ]. Furthermore the concentrations of NT-proBNP between every 2 subgroups with different type cardiovascular diseases had significant differences and they also increased with the increased severity of heart failure according to NYHA functional classification （P 〈 0. 001 ）. There are significant differences between every 2 subgroups with different type cardiovascular diseases among the patients with NYHA functional clase I or with clase 11 respectively. Multi-varietic regression analysis showed that there were significant positive correlations between NT-proBNP concentrations and NYHA functional classification, age （r = 0. 712, P 〈 0. 001 and r = 0. 063, P 〈 0. 001, respectively）. Conclusion The plasma levels of NT-proBNP increase significantly with the increased severity of heart failure （ NYHA functional classes）. At the early stage of cardiac function injury, different cardiovascular diseases may contribute to the increase of plasma NT-proBNP differently.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2006年第1期31-34,共4页
Chinese Journal of Laboratory Medicine
作者简介
丛祥凤，电子信箱：xiangfeng_cong@yahoo．com．cn
