摘要
目的:比较乌拉地尔和尼卡地平治疗高血压急症的疗效和不良反应.方法:78例高血压急症病人分为乌拉地尔组和尼卡地平组,每组39例,乌拉地尔组先予12.5～25 mg ,iv,后以4 μg·kg-1·min-1,iv,gtt,根据血压情况调整滴速,最大维持量12 μg·kg-1·min-1.尼卡地平组先予2 mg,iv,然后以1 μg·kg-1·min-1,iv,gtt,根据血压变化调整滴速,最大维持量6 μg·kg-1·min-1.记录用药前后血压、心率等指标的变化.结果:乌拉地尔和尼卡地平组显效、有效和无效分别为36,3,0例和34,4,1例,2组疗效无显著差异(P >0.05),但治疗后乌拉地尔组心率明显下降,尼卡地平组心率明显上升,两者比较差异非常显著(P <0.01);尼卡地平组治疗后最大降压效果出现时间明显迟于乌拉地尔组(P<0.01);心绞痛发作和脑出血加重人数多于乌拉地尔组;不良反应率也高于乌拉地尔组.结论:2种药物治疗高血压急症均效果良好,但乌拉地尔起效更快、应用更安全、适用范围更广.
AIM： To compare the therapeutic effects and adverse reactions of urapidil and nicardipine injection in treating hypertensive emergency. METHODS ： Seventy-eight patients with hypertensive emergency were randomized into two groups：the urapidil group and the nicardipine group, including 39 ones in each. The former received urapidil 12.5 - 25 mg, iv first, and followed by 4 μg·kg^-1·min^-1 intraven eously with the maximum maintaining does of 12 μg·kg^-1·min^-1 regulated by changes of blood pressure. The latter received nicardipine 2 mg, iv first , and then followed by 1 μg·kg^-1·min^-1 intraveneously with maximum maintaining dose of 6 μg·kg^-1·min^-1 mln regulated according to the changes of blood pressure. Parameters such as blood pressure and heart rate before and after the treatment were recorded. RESULTS： The clinical efficacies including excellent response , response and no response recorded as individual number for urapidil vs nicardipine group were 36, 3,0 vs 34,4,1 respectively with no significant differ- ence between the two groups（P 〉 0.05）. The heart rates in urapidil group decreased obviously and those of the nicardipine group increased significantly, showing conspicuous difference （P 〈 0.01 ）. The onset with maximum decrease of blood pressure in nicardipine group was inferior to that of urapidil group（P 〈0.01 ）. The incidence of angina, aggravation of cerebral bleed- ing and rate of adverse reaction were also high in nicardipine group than those of the urapidil group. CONCLUSION： Intravenous urapidil and nicardipine are both effective in treating hypertensive emergency , buturapidil functions more rapidly, safer and apt to be recommended extensively.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2005年第10期795-798,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
乌拉地尔
尼卡地平
高血压
急症
urapidil
nicardipine
hypertension
emergencies
作者简介
宋尚明（1964-），男，山东淄博人，副主任医师，博士研究生，主要从事心血管病诊治研究。[联系人]宋尚明。Phn：86-531-793-8911，ext2368。E-mail：shmingsong@163．com
