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盐酸氟西汀治疗首发抑郁症患者脑局部葡萄糖代谢变化的PET研究 被引量：2

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摘要 目的探讨首发抑郁症患者经盐酸氟西汀治疗后脑葡萄糖代谢率的变化。方法8例首发抑郁症患者经盐酸氟西汀 治疗前、后进行正电子发射断层扫描术(positron emission tomographyr,PET),并采用统计参数地图(SPM,P值设为0．001)方法分析。 以汉密顿抑郁量表(HAMD)、Montgomery-Asberg抑郁量表(MADS)、汉密顿焦虑量表(HAMA)、临床疗效总评量表(CGI)、中国修订韦 克斯勒成人智力量表(WAIS-RC)、中国修订韦克斯勒记忆量表(WMS—RC)、威斯康星卡片分类测验(WCST)评价临床症状改善及神 经心理变化。结果SPM分析显示,首发抑郁症经盐酸氟西洒治疗有效者的左侧额上回、左侧额中回、右侧脑岛、左侧顶上小叶、右侧 顶下小叶及右侧小脑后叶的局部葡萄糖代谢率显著高于治疗前(P<0．001);左侧丘脑、左侧豆状核的局部葡萄糖代谢率显著低于治 疗前(P<0．001)。结论盐酸氟西汀可使首发抑郁症患者的前额叶皮质、丘脑的局部葡萄糖代谢率发生变化。
作者 张选红 江开达 左传涛 曹秋云 赵军
机构地区 上海精神卫生中心 复旦大学附属华山医院PET中心 南京鼓楼医院心理科
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2005年第5期364-366,后插3,共4页 Chinese Journal of Nervous and Mental Diseases
关键词 抑郁症 正电子发射断层扫描术 脱氧葡萄糖 盐酸氟西汀
分类号 R749.4 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献10

  • 1费立鹏.中国的精神卫生问题——21世纪的挑战和选择[J].中国神经精神疾病杂志,2004,30(1):1-10. 被引量：152
  • 2昂秋青,江开达,张明园,赵晋华,林祥通.老年期抑郁症的单光子发射计算机断层扫描研究[J].中国神经精神疾病杂志,2003,29(4):272-275. 被引量：16
  • 3American Psychiatric Association. Diagnostic and Statistical Manual of mental Disorders. 4th ed. Washington DC: American Psychiatric Association, 1994.706 -708.
  • 4Den Hartog HM, Derix MM, Van Bemmel AL, et al. Cognitive functioning in young and middle - aged unmediated out-patients wirh major depression: test the effort and cognitive speed hypotheses. Psychol Med, 2003,33(8): 1443.
  • 5Talariach J, Toumoux P. Co-Planar stereotasic Atlas of the Human Brain. New York: Thieme Medical, 1998,100 ～ 105.
  • 6Dreves WC. Neuroimaging studies of mood disorders. Boil Psychiatry,2000,48(8) :813.
  • 7Dolan RJ, Bench C J, Liddle PF, et al. Dorsolateral prefrontal cortex dysfunction in the majorpsychoses; symptom or disease specificity?Neurosurg Psychiatry, 1993,56(10) :1290.
  • 8Sidney H, Kenneth R, Stephanie K, et al. Changes in regional brain glucose metabolism measured with positron emession tomography after parosetine treatment of major depression. Am J Psychiatry, 2001,158(6) :899.
  • 9Dunn RT, Kimbrell TA, Ketter TA, et al. Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depression. Biol Psychiatry,2002,51 (5) :387.
  • 10Ketter Ta, Kimbrell Ga, Geogre Ms, et al. Effects of mood state and illness course on cerebral glucose metabolism in bipolar disorders. Biol Psychiatry ,2001 (2) ,49:97.

二级参考文献14

  • 1中国卫生年鉴委员会.中国卫生年鉴1992[M].北京：人民卫生出版社,1992.637-638.
  • 2Cummings JL.Congnitive and behavioral heterogeneity in Alzheimer'sdisease:seeking the neurobilological bassi.Neurobiol Aging, 2000, 21(6): 845.
  • 3Nobler MS, Pelton GH, Sackeim HA. Cerebral blood flow and mebabolism in late-life depression and depression. J Geriatr Psychiatry Neural, 1999, 12(3): 118.
  • 4Narayan M, Bremmer JD, Kumar A. Neuroenatomic substrates of late-life mental disorders.J Geriatr Psychiatry Neurol, 1999, 12(3): 95.
  • 5Meltzer CC, Smith G, Dekosky ST,et al. Serotonine in aging, late-life depression ,and Alzheimer'sdisease:the emerging role of functional imaging.Neuropsychophamacology, 1998, 18(6): 407.
  • 6Bearden CE, Hoffman KM, Cannon TD. The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disord,2001, 3(3): 106.
  • 7Kunmr A, Miller D. Neuroimaging in late-life mood disorder. Clin Neurosci, 1997, 4(1): 8.
  • 8Nobler MS, Mann J J, Sackeim HA. Serotonin, central blood flow, and central metabolic rate in gerriatric major depression and normal aging.Brain Res Rev, 1999, 30(3): 250.
  • 9Reisberg B,Franssen EH,Hasan SM,et al.Retrogenesis:clinical,physiologic,and pathologic mechanisms in brain aging,alzheimer's disease and other dementing processed.Eur Arch Psychiatry Clin Neurosci,1999,249(3): 28.
  • 10Scheltens P, Korf ES. Contribution of neuroimaging in the diagnosis of Alzheimer's disease and other dementias. Curt Opin Neurol, 2000, 13(4) : 391.

共引文献166

同被引文献30

  • 1张选红,江开达,左传涛,王立伟,曹秋云,赵军.首发抑郁症患者局部脑葡萄糖代谢的PET初步研究[J].上海精神医学,2004,16(3):129-135. 被引量：14
  • 2徐伊 ,徐浩 ,贾艳滨 ,徐安定 .抑郁症患者局部脑血流变化的SPECT研究[J].中国神经精神疾病杂志,2005,31(3):206-209. 被引量：17
  • 3吴志国,谢斌,方贻儒.抗抑郁治疗的PET研究[J].上海精神医学,2006,18(6):368-371. 被引量：1
  • 4Greeuberg P,Corey-Lish PK,Bimbanm H,et al.Economic implications of treatment-reaistant depression among employees[J].Pharmacoeconomics,2004,22(6):363 -373.
  • 5Seminowiez DA,Mayberg HS,Melntosh AR,et al.Limbic-frontal circuitry in major depression:a path modeling metanalysis[J].Neurolmage,2004,22(1):409 -418.
  • 6Mayberg HS.Modulating dysfunctional limbic-eorfieal circuits in depression:towards development of brain-based algorithms for diagnasis and optimized treatment[J].Br Meal Bull,2003,65(1):193-207.
  • 7Thase ME,Rush AJ.When at first you don't succeed:sequential atrategies for antidepressant nonresponders[J].J Chn Psychiatry,1997,(suppl 13):23-29.
  • 8Fujimoto T,Takeuehi K,Matsumoto T,et al.Metabolic ehangos in the brain of patients with late-anset major depression[J].Psychiatry Res,2008,164(1):48-57.
  • 9Kennedy SH,Evans KR,Krttger S,et al.Changes in regional brain glucose metabolism measured with positron emission tomography after paroxefine treatment of major depression[J].Am J Psychiatry,2001,158(6):899 -905.
  • 10Kimbrell TA,Ketter TA,George MS,et al.Regional cerebral glucose utilization in patients with a range of severities of unipolar depression[J].Biol Psychiatry,2002 ; 51(3),237-252.

引证文献2

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中国神经精神疾病杂志
2005年 第5期

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