摘要
目的评价艾司西酞普兰合并认知治疗对酒依赖伴抑郁障碍的临床疗效及安全性。方法采用随机数字法将62例伴抑郁障碍的酒依赖患者分成艾司西酞普兰合并认知治疗组(研究组)和单用艾司西酞普兰治疗组(对照组)各31例,治疗8周,于治疗前及治疗后第1、2、4、8周末采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、临床总体印象量表(CGI)及治疗中出现的症状量表(TESS)评定临床疗效及不良反应。结果治疗后第2、4、8周末两组HAMD、HAMA及CGI评分与治疗前比较差异均有统计学意义(P<0.01);两组间HAMD、HAMA及CGI评分在治疗后第1、2、4、8周末比较差异均有统计学意义(P<0.05或0.01);两组有效率分别为93.55%和74.20%,差异有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论艾司西酞普兰合并认知治疗对酒依赖伴抑郁障碍的疗效优于单用艾司西酞普兰,且起效更快,不良反应相当。
Objective To explore the clinical efficacy and safety of escitalopram combined with cognitive therapy in the treatment of alcohol dependent patients with depression disorder. Methods 62 alcohol dependence patients with depression disorder were randomly assigned to the treatment groups for escitalopram combined with cognitive therapy（ research group） or single escitalopram （ contrast group） treatment for 8 weeks. The curative effects and adverse reactions were assessed with the Hamilton depression scale （HAMD）, Hamilton anxiety scale （HAMA）, Clinical general impression （CGI） and treatment emergent symptom scale （TESS） respectively at baseline and 1,2,4 ,Sweek. Results The scores of HAMD, HAMA and CGI are significantly lower after 2 ,4,8weeks treatment in both groups（P 〈 0.01 ）. The significant improvement were found in the research group at the end of first week treatment（P 〈0.01 ） ,which suggest that the research group took effects faster. The scores of HAMD , HAMA and CGI in the research group are significant than the contrast group after 1,2,4,8weeks treatment （ P 〈 0.05 or P 〈 0.01 ）, the research group decreased more significantly. Effective rate of the research group was 93.55% and of the contrast group was 74.20%, the difference was significant （P 〈 0.05 ）. The side effects were no significant between two groups （P 〉 0.05 ）. Conclusion Eseitalopram combined with cognitive therapy can increase curative effect and shorten the period of treatment.
出处
《四川精神卫生》
2013年第3期237-240,共4页
Sichuan Mental Health
关键词
艾司西酞普兰
认知治疗
酒依赖
抑郁
Escitalopram Cognitive therapy Alcohol ＆pendence Depression
作者简介
通讯作者：段丽娟，E—mail：danqiyiren@163．com
