摘要
目的探索精神分裂症事件相关电位(ERPs)特征及非典型抗精神病药物治疗对其的影响。方法22例从未用过抗精神病药或停药两周以上的精神分裂症患者以及15例健康受试者进行ERPs检查。然后22例患者分别给予利培酮或氯氮平治疗6周,观察治疗后患者ERPs的变化经情况。结果与正常受试者比较,治疗前精神分裂症患者表现P3波幅降低,治疗后P3幅值降低得到改善。利培酮治疗可明显增加P3幅值,氯氮平治疗P3幅值增加较少。结论精神分裂症患者ERPs异常主要表现P3幅值降低,利培酮治疗可显著改善这种异常。
Objective To study the cognitive deficit and atypical antipsychotics＇ effects on it in schizophrenic patients. Methods A total of 22 patients with schizophrenia who were drug-naive or drug-free for at least two weeks were compared with 15 healthy controls in the Event-related Potentials （ERPs） profiles. Of the patients group 12 and 10 patients were given risperidone and elozapine respectively for 6 weeks. The changes in ERPs profiles were observed. Results Compared with controls,the drug-free patients manifested lower P3 amplitude. After treatment, P3 amplitude defect in patients was improved. There were more improvement of P3 amplitude in risperidone group than in clozapine group. Conclusion The defect of ERPs in schizophrenic patients is mainly showed in P3 amplitude. Risperidone might improve the defect.
出处
《山东精神医学》
2005年第4期217-219,共3页
Shangdong Archives of Psychiatry
关键词
精神分裂症
事件相关电位
利培酮
氯氮平
Schizophrenia Event-related Potentials Risperidone Clozapine
作者简介
孙兆明（1972-），男，山东博山人，博士生
