摘要
为了探讨急性脑卒中患者血小板超微结构的变化，采用ＤＸＡ４～１０型电子显微镜对５０例急性脑卒中患者血小板中α颗粒数及每平方微米中血小板α颗粒数进行观察。结果：脑卒中组上述指标显著低于对照组（Ｐ＜０．０１）。其中缺血性脑卒中者降低更显著（Ｐ＜０．００１）。梗塞面积大于５ｃｍ的患者α颗粒较小面积损伤者显著减少（Ｐ＜０．０５），而与梗塞部位无关。血液稀释和阿司匹林（ＡＳＡ）治疗后α颗粒数减少显著改善（Ｐ＜０．０５）。另外还发现，血小板α颗粒减少与血钙减少呈正相关（ｒ≥０．３４，Ｐ＜０．０５）。结果提示，血小板超微结构的改变可作为判断脑卒中诊断、治疗及预后的客观指标。
Thetotalnumber,areaandthenumberperμm2ofα-particlesofplateletsweremea-suredwithaDXA4-10electronmicroscopein50casesofacutecerebralstroke.Theresultsshowedthattheindicesinthestrokegroupweresignificantlylowedthanthoseinthenormalcontrols(P<0.01);ofthosestilfurtherlowedisintheischemicstroke(P<0.001)andtheα-particlesinthepatientswithacerebralinfarctionareaover5cm2weremardedlyreducedthanthosewihtthesmalerones(P<0.05).Itwasfoundthattheα-particleswerenotrelatedtothelocationsoftheinfarctions.AfterthetreatmentwithblooddilutionandASA,thenumberoftheα-partidesincreasedmarkedly(P<0.05).Thisstudyalsosuggestedthatthedecreaseoftheα-particleswaspositivelycorrealtedwiththedecreaseofbloodcalcium(r=0.34,P<0.05).Theauthorsconsiderthattheultrastructureofplateletmayreflectareliableandobjectiveindexinthejudgmentofdiagnosis,treatmentandprogno-sisofthecerebralstroke.
出处
《中华神经科杂志》
CAS
CSCD
1996年第1期45-48,共4页
Chinese Journal of Neurology
关键词
中风
血小板
超微结构
CerebrovasculardiseasePlateletUltrastructure
