摘要
我们用透射电镜观察血小板面积和α颗粒,放免法测定血浆 TXB_2和6-酮-PGF_1α含量,急性缺血性卒中患者14例,正常对照组15例。结果显示病例组血小板α颗粒数明显减少(P<0.001),临床病情较重者减少更明显(P<0.01),血浆 TXB_2含量增高显著(P<0.01),病例组与对照组血小板面积和6-酮-PGF_1α的变化无区别(P>0.05)。这些观察证实急性缺血性卒中存在血小板分泌增加,可能是与血小板聚集、血管机械阻塞引起脑梗塞的发病机理的重要区别。
We used transmission electron microscopy to count the alpha granules containedwithin platelets and serial radio-immunoassay was used to determine the plasma TXB_2level from 14 acute ischemic stroke patients and 15 healthy controls.Compared withthose from controls,platelets from stroke patients contained significantly fewer alphagranules(p<0.001) and platelet area showed no change(p>0.05),The results showedthat the excretion of TXB_2 in patients was obviously higher than that in normal con-trols(p<0.01),the more severe the clinical course,the lower the patient's alpha gra-nules(p<0.01).These observations support the prssence of increased platelet secretionassociated with acute ischemic stroke and raise the possibility that platelet secretionmay be an important difference to the mechanical occlusion of blood vessels by plateletaggregates in the pathogenesis of cerebral infarction.
出处
《上海医学》
CAS
CSCD
北大核心
1993年第9期501-503,共3页
Shanghai Medical Journal
关键词
血小板
α颗粒
中风
血栓烷
Acute ischmic stroke
Platelet alpha granule
TXB_2
