摘要
①目的探讨P53和P21蛋白异常表达在胃癌发生发展中的作用。②方法应用免疫组化技术检测58例胃癌及相应癌旁组织中P53和P21蛋白的表达。③结果胃癌组织P53蛋白阳性表达率为86.21%(50/58),癌旁组织P53蛋白均为阴性表达,胃癌组织P53蛋白阳性表达率明显高于癌旁组织,差异具有极显著性(P=0.000)。胃癌组织P21蛋白阳性表达率为62.07%(36/58),癌旁组织P21蛋白阳性表达率为89.66%(52/58),胃癌组织P21蛋白阳性表达率明显低于癌旁组织,差异有极显著性(2χ=12.5,P<0.01)。胃癌组织中P21与P53蛋白共同阳性表达率为56.9%,但两者无相关性(χ2=1.323,r=0.203,P>0.05)。④结论P53和P21蛋白表达异常与胃癌发生有关。
Objective To investigate the role of abnormal expression of P53 and P21 proteins in the oncogenesis and development of gastric carcinoma. Methods P53 and P21 protein expression were measured by immunohistochemistry in 58 gastric carcinomas and corresponding adjacent tissues. Results P53 immunoreactivity was detected in 50 of 58 gastric carcinomas, but not in the 58 corresponding adjacent normal tissues. The difference was significant between the two groups （P=0.000）. P21 immunoreactivity was detected in 36 of 58 gastric carcinomas, and in 52 of 58 corresponding adjacent normal tissues. The difference was also significant （x^2 =12.5, P〈0.01）. The co-expression positive rate of P21 and P53 in gastric carcinoma tissues was 56.9%. But there was no significant correlation between P21 and P53 expression （x^2=1.323 ,r=0.203 ,P〉0.05）. Conclusion The abnormal expression of P53 and P21 proteins is related with the oncogenesis of gastric carcinoma.
出处
《青岛大学医学院学报》
CAS
2005年第3期223-225,共3页
Acta Academiae Medicinae Qingdao Universitatis
作者简介
时飞（1964-），女，副主任医师。
