摘要
目的:探讨p21WAF1 在肾母细胞瘤中的表达水平,评价p21WAF1 的检测对肾母细胞瘤的诊断和预后判断的应用价值。方法:用免疫组织化学技术检测32 例小儿肾母细胞瘤(肿瘤组)和7 例小儿非瘤肾组织(对照组)石蜡标本中p21WAF1的表达,分析p21WAF1 的表达与肾母细胞瘤组织学分型、临床肿瘤分期和淋巴结转移间的关系。结果: 1) p21WAF1 在非瘤肾组织中存在基础水平的表达; 2) p21WAF1 在肾母细胞瘤中的表达与其组织学分型、临床肿瘤分期和淋巴结转移相关。结论: p21WAF1 的表达在一定程度上有助于肾母细胞瘤的诊断和预后判断。
OBJECTIVE:To investigate the expression of p21 WAF1 in children's nephroblastoma and its clinical significance.METHODS:Thirty-two children′s nephroblastoma (tumor group) and 7 benign nephridium (control group) tissues from surgical resections were collected. The expression of p21 WAF1 was detected by immunohistochemistry.The results were analyzed by using SPSS 10.0 statistical software.RESULTS: 1) There was a basic expression of p21 WAF1 in the benign nephridium tissue. 2) The expression of p21 WAF1 was associated with its histopathologic type, clinical tumor stage and status of lymph node metastasis.CONCLUSION:The expression of p21 WAF1 is very useful for nephroblastoma diagnosis and the evaluation of prognosis.
出处
《肿瘤防治杂志》
CAS
2005年第9期690-692,共3页
China Journal of Cancer Prevention and Treatment
