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重视老龄化对创面愈合影响的研究 被引量：14

Aging and its effects on wound healing
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摘要 机体老龄化将带来一系列病理生理变化,其中也将对创面愈合产生影响。本文从营养、免疫调控、激素与内分泌多个方面综述老龄化对创面愈合产生的影响。 To initiate a more comprehensive understanding of aging and its effects on wound healing, the changes of nutrition, immune regulation, hormone and endocrine with the aging and their effects on wound healing were reviewed.
作者 付小兵 程飚
机构地区 解放军总医院第 广州军区总医院整形外科
出处 《创伤外科杂志》 2005年第5期385-387,共3页 Journal of Traumatic Surgery
关键词 老年 创伤愈合 aging wound healing
分类号 R329.1 [医药卫生—人体解剖和组织胚胎学]
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参考文献20

  • 1Ashcroft GS,Ashworth JJ.Potential role of estrogens in wound healing[J].Am J Clin Dermatol,2003,4:737-743.
  • 2Ashcroft GS,Mills SJ,Flanders KC,et al.Role of Smad3 in the hormonal modulation of in vivo wound healing responses[J].Wound Repair Regen,2003,11:468-473.
  • 3Matsuda T,Yamamoto T,Muraguchi A,et al.Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3[J].J Biol Chem,2001,276:42908-42914.
  • 4付小兵,程飚.老年化皮肤特点与创面愈合的关系[J].中华老年多器官疾病杂志,2002,1(3):229-231. 被引量：12
  • 5Shan MG,Maibach HI.Estrogen and skin. an overview[J].Am J Chin Dermatol,2001,2:143-150.
  • 6Weihua Z,Andersson S,Cheng G,et al.Update on estrogen signaling[J].FEBS Lett,2003,546:17-24.
  • 7Gosain A,DiPietro LA.Aging and wound healing[J].World J Surg,2004,28:321-326.
  • 8Reed MJ,Edelberg JM.Impaired angiogenesis in the aged[J].Sci Aging Knowledge Environ,2004,18:7.
  • 9Swift ME,Burns AL,Gray KL,et al.Age-related alterations in the inflammatory response to dermal injury[J].J Invest Dermatol,2001,117:1027-1035.
  • 10Boehmer ED,Goral J,Faunce DE,et al.Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression[J].J Leuk Biol,2004,75:342-349.

二级参考文献24

  • 1[1]Thomas DR. Age-related changes in wound healing. Drugs Aging, 2001, 18: 607-620.
  • 2[2]Margolis DJ, Bilker W, Santanna J, et al. Venous leg ulcer: incidence and prevalence in the elderly. J Am Acad Dermatol, 2002, 46: 381-386.
  • 3[4]Ballas CB, Davidson JM. Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations. Wound Rep Reg,2001, 9: 223-237.
  • 4[5]Casey G. Physiology of the skin. Nurs Stand, 2002, 16:47-51.
  • 5[6]Uitto J, Bernstein EF. Molecular mechanisms of cutaneous aging: connective tissue alterations in the dermis. J Invest Dermatol Symup Proc, 1998, 3: 41-44.
  • 6[7]Kerezoudi E, Thomas PK. Influence of age on regeneration in the peripheral nervous system. Gerontology, 1999, 45:301-306.
  • 7[8]Chang E, Yang J, Nagavarapu U, et al. Aging and survival of cutaneous microvasculature. J Invest Dermatol,2002, 118: 752-758.
  • 8[9]Ashcroft GS, Mills SJ. Androgen receptor-mediated inhibition of cutaneous wound healing. J Clin Invest, 2002, 110:615-624.
  • 9[10]Laube S, Farrell AM. Bacterial skin infections in the elderly: diagnosis and treatment. Drugs Aging, 2002, 19: 331-342.
  • 10[11]Swift ME, Kleinman HK, DiPietro LA. Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest,1999, 79: 1479-1487.

共引文献11

同被引文献246

引证文献14

二级引证文献151

创伤外科杂志
2005年 第5期

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