摘要
将妊娠28周的受试孕妇随机分为4组,分别1次性口服维生素D(VD)10万IU或肌注VD10万IU或20万IU,对照组口服空白胶囊.结果3个补充组产妇血和脐血25-(OH)D水平以及产妇血钙水平显著高于对照组(P<0.05),而产妇血和脐血25-(OH)D小于27.3nmol/L(11ng/ml)的发生率以及孕后期腿抽筋的发生率显著低于对照组,补充组产妇血25-(OH)D水平高于其妊娠28周时的水平.补充组未发现先天性佝偻病,而对照组先天性佝偻病和可疑先天性佝偻病的发生率显著高于补充组。结果提示孕后期补充VD可明显改善孕妇和胎儿的VD和钙的营养状况.预防先天性佝偻病,品服与肌泣10万IU与20万IU效果相同.
A single dose of vitamin D 100 000IU or 200 000IU was administered or intramuscularly injected to pregnant women at the 28th week of pregnancy. Serum 25-(OH) D of supplemental groups at perinatal period was higher significantly than that at the seventh month of pregnancy, and higher significantly than that of control group at perinatal period. The cord serum 25-(OH)D and perinatal serum calcium of the mother in supplemented groups were higher significantly than that in the control group. The occurrence of legs cramps during the 3rd trimester were less significantly in the supplemented groups than that in the control group. The incidence of maternal and cord serum 25-(OH)D below 27. 3 nmol/L(11ng/ml)at perinatal period,and the incidence of suspicious congenital rickets were significantly lower in the supplemented groups than that in the control group. It is suggested that vitamin D supplementation during the pregnancy trimester may improve vitamin D and calcium status of both pregnant women and fetus, also it could prevent fetus from congenital rickets. Neither the difference between oral administration and intramuscular injection nor the variation between 100 000IU and 200 000IU was found.
