摘要
目的观察中国汉族不同人群STR等位基因频率对联合父权指数(CPI)的影响。方法随机取108例13个CODIS基因座分型结果不排除父权关系的三联体案和二联体案,用5个不同地区人群的等位基因频率计算CPI值。结果三联体案的CPI值在2077.63～50897711626.46之间,同一案例的最大CPI与最小值CPI之比大于100者有20例(19.52%);二联体案的CPI值在25.12～2998685141之间,同一案例的最大CPI与最小值CPI之比大于100者有13例(12.04%)。结论不同人群等位基因频率计算CODIS基因座所得的CPI值在部分亲权鉴定案中有很大的差异。为了防止等位基因频率不确定性带来的误差,建议在亲权鉴定中用保守法计算CPI值。
Objective To evaluate the diversity of combined paternity index （CPI） of multiple STR loci when different population allele frequencies was used to calculate the paternity index. Methods CPI of 13 CODIS （combined DNA index system） loci for 108 trio cases and 108 duo cases selected randomly were calculated by using five Chinese Han population allele frequencies, respectively. Results The CPI range for trio cases and duo cases were 2077.63-50 897 711 626.46 and 25.12-2998 685 141, respectively. When different population allele frequencies were applied to the same case, the ratio of maximum CPI and minimum CPI, which was more than 100, for trio cases and duo cases were 20 cases（19.52%） and 13 cases （12.04%） , respectively. Conclusion The variation of CPI value of the CODIS loci was obvious with different allele frequencies. To prevent the error causing by uncertain allele frequencies, a conservative CPI value should be calculated in paternity testing.
出处
《法医学杂志》
CAS
CSCD
2005年第3期197-199,共3页
Journal of Forensic Medicine
关键词
亲权鉴定
父权指数
等位基因频率
STR
CODIS
paternity testing
paternity index
allele frequencies
short tandem repeats
CODIS
作者简介
吕德坚（1966-），男，广东玉林人，博士，主要从事法医物证学研究。
陆惠玲，副教授，主要从事法医物证学研究。
