摘要
目的观察不同剂量阿托伐他汀对急性心肌梗死(AMI)患者预后的影响。方法将2008-06-2009-06收治的102例急性心肌梗死(AMI)患者随机分为两组,每组51例,观察组常规治疗加上阿托伐他汀20mg/d,对照组常规治疗加上阿托伐他汀10mg/d。两组均在治疗前及治疗后90d测定血脂四项、C反应蛋白(CRP)和NO浓度,并且观察再发不良心血管事件的发生情况。结果两组治疗后血脂水平有不同程度的降低,与对照组比较,观察组降低的更明显(P<0.05),两组治疗后CRP降低而NO升高,观察组与对照组比较效果更明显(P<0.05),两组患者不良事件发生情况,观察组与对照组比较明显降低(P<0.05)。结论阿托伐他汀强化治疗能改善急性心肌梗死(AMI)患者的预后,每天剂量40mg是安全的,他汀类药物对冠心病患者防治有重要意义。
Objective To observe the influence of different doses of atorvastatin on the prognosis of Acute Myocardial Infarction. Methods 102 cases of patients treated with Acute Myocardial Infarction from June 2008 to June 2008 were randomly divided into two groups of 51 cases of each group,the observation group with conventional therapy plus atorvastatin 20 mg/d,the control group with conventional treatment plus atorvastatin 10 mg/d. Both groups were measured before and after 90d treatment at the four lipids,C-reactive protein(CRP)and NO concentration,and were observed of Re-angina occurrence of cardiovascular events.Results The lipid levels of two groups have varying degrees of reduction after treatment.Compared with the control group,the observation group is more obvious(P<0.05).The two groups both reduce CRP and increase NO level after treatment.Compared with the control group,the effect of the observation group is more obvious(P<0.05).With the occurrence of adverse events,the observation group decreased significantly compared with the controlgroup(P<0.05).Conclusion Atorvastatin therapy can improve prognosis of patients with Acute Myocardial Infarction. 40 mg dose every day is safe. Statin drug on prevention and control of coronary heartdisease has important significance.
出处
《慢性病学杂志》
2010年第12期1626-1628,共3页
Chronic Pathematology Journal
关键词
庚酸类/治疗应用
吡咯类/治疗应用
心肌梗死/药物疗法
急性病
治疗结果
人类
Heptanoic Acids/therapeutic use
Pyrroles/therapeutic use
Myocardial Infarction/drug therapy
Acute Disease
Human
Treatment Outcome
