摘要
目的:研制复方左氧氟沙星锌乳膏并建立其质量控制方法。方法:取左氧氟沙星和硫酸锌制成左氧氟沙星锌,加入基质制备乳膏;采用紫外分光光度法于293nm波长处测定左氧氟沙星含量。结果:制备的乳膏均匀细腻,易于涂布;左氧氟沙星检测浓度在2～10μg/ml范围内线性关系良好(r=0.9999,n=5),平均回收率为99.8%,RSD=0.44%(n=5)。结论:本制剂组方合理,制备工艺简便可行,质量稳定可控。
OBJECTIVE： To prepare compound levofloxacin zinc cream and establish its quality control. METHODS：Levofloxacin zinc was made from levofloxacin and zinc sulfate, the cream was prepared by adding ground -substance to levofloxacin zinc; The content of levofloxacin was determined by ultraviolet spectrophotometry with the wavelength set at 293nm.RESULTS： The prepared cream was even, fine and easy to spread; The calibration curve of levofloxacin was linear in the range of 2-10μg/ml （ r=0.9 999,n =5）, the average recovery rate was 99.8%, RSD = 0.44（n = 5）. CONCLUSION： The formulation of the preparation is reasonable and the preparation technics was simple and feasible, the quality is stable and controllable。
出处
《中国药房》
CAS
CSCD
北大核心
2005年第16期1231-1232,共2页
China Pharmacy
关键词
复方左氧氟沙星锌乳膏
制备
质量控制
Compound levofloxacin zinc cream
Preparation
Quality control
作者简介
主管药师。研究方向：医院制剂、临床药学、药事管理。电话：0395—7121573—8013。E—mail：tian0331@163．com
