摘要
将豚鼠（ｎ＝９）暴露于２００ｍｇ／Ｌ的血小板活化因子（ＰＡＦ）气雾，２４小时后测定豚鼠对组胺的气道反应性，然后进行支气管肺泡灌洗（ＢＡＬ）。ＰＡＦ处理组的气道反应性显著高于对照组（ｎ＝７，Ｐ＜０．０１），ＢＡＬ嗜酸性粒细胞（Ｅｏｓ）、低密度Ｅｏｓ（ＨＥｏ）也显著增多（Ｐ＜０．００１）。ＢＡＬＥｏｓ与气道反应性ＰＣ＿（２０）值呈显著负相关（ｒ＝－０．６２，Ｐ＜０．０５），但ＰＣ＿（２０）值与ＨＥｏ的关系更为密切（ｒ＝－０．８４，Ｐ＜０．０１）。ＰＡＦ组ＢＡＬＨＥｏ的过氧化物酶（ＥＰＯ）含量显著低于正常密度Ｅｏｓ（Ｐ＜０．０５）。以上表明ＰＡＦ是诱导气道高反应性的重要介质，其作用机制可能与趋化、活化Ｅｏｓ有关。
xposure of guinea pigs to aerosols of 200μg/mlplatelet-activating factor 24h later,airway hyperrespon-siveness to histamine induced and number of eosinophilsand hypodense eosinophils in bronchoalveolar lavage flu-id(BALF)increased,comparing with the controlgroup. The number of eosinophils in BALF was corelat-ed with PC_(20) value in PAF-treated group(r=-0.62,P<0. 05).However,the percentage of hypodenseeosinophil in BALF had choser rela tion to airway respon-siveness(r=-0. 84,P<0. 01).The content of perox-idase in hypodense eosinophils in BALF for guinea pigstreated by inhalation of PAF was lowered markedlythan that in normodense eosinophil(P<0. 05).The re-sult suggested that chemotaxis and activation ofeosinoph ils by PAF might play an important role in air-way hype rresponsiveness.
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
1995年第3期155-157,共3页
Chinese Journal of Tuberculosis and Respiratory Diseases
关键词
血小板激活因子
气道反应性
哮喘
动物模型
Eosinophils Platelet activating fac-tor Airway hyperresponsiveness.
