摘要
用过氧化物酶抗过氧化物酶法，检测１９例婴儿巨细胞病毒性肝炎患儿外周血淋巴细胞、单核细胞、粒细胞中人巨细胞病毒前早期抗原、早期抗原、晚期抗原，并对其中５例作了恢复期复查。结果表明，急性期大都伴有白细胞受感染，三类细胞之间感染阳性率无显著性差异，恢复期白细胞受感染极少；三种抗原在白细胞中的产生有差异，表达前早期抗原、早期抗原的居多，表达晚期抗原的较少。先天感染患儿抗原阳性的淋巴细胞、单核细胞占总细胞的百分比明显高于围生期感染者。提示婴儿巨细胞病毒性肝炎患儿免疫细胞易受巨细胞病毒感染。
mmediate early antigen (IEA), early antigen(EA) and late antigen (LA) of human cytomegalovirus(HCMV) in peripheral blcod leukocytes were detectedin 19 patients with infantile HCMV hepatitis by peroxi-dase-anti-peroxidase (PAP) method. Five of these casesreceived second examination during convalescence. Mostof the patients’ leukocytes were positive for HCMVantigen in acute phase. No significant differences in pos-itive rates of HCMV antigen were found among thepolymorphonuclear cells, lymphocytes and monocytes.During convalescence, leukocytes were occasionally posi-tive for HCMV antigen. Positive rates of HCMV IEA ,and EA in leukocytes were much higher than that ofHCMV LA- It was also found that more mononuclearcells were infected with HCMV in patients who got theinfection in utero.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1995年第1期10-12,共3页
Chinese Journal of Pediatrics
