摘要
目的:研究影响胃舒胶囊制备的各种因素,确定最佳工艺条件。方法:用正交实验L9(34)设计安排实验,分别以盐酸小檗碱含量和甘草次酸含量作为考察指标,优选胃舒胶囊制备过程中醇提和水提工艺。结果:胃舒胶囊最佳醇提工艺为药材8倍量70%乙醇提取3次,2h/次;最佳水提工艺为药材粒度3～10mm,7倍药材量水提取3次,3h/次。结论:该方法可用于胃舒胶囊的工业化生产。
Objective:To optimize the technical parameters of Weishu Capsules through controlling the different factors.Methods:Factors for the ethanol extraction and water extraction were studied by orthogonal experiment designs using berberine hydrochloride and glycyrrhetinic acid as index respectively.Results:The optimum conditions for the manufacture of Weishu Capsules were to soak the ethanol soluble medicinal materials in 10 times amount of 80% ethanol for two hours and water soluble medicinal materials in 7 times amounts of water soluble medicinal materials for 3 hours with the granularity size 3～10mm.Conclusion:The technology is available for industrial production.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2005年第7期629-630,共2页
Lishizhen Medicine and Materia Medica Research
关键词
胃舒胶囊
正交实验法
盐酸小檗碱
甘草次酸
Weishu capsules
Orthogonal experiment
Berberine hydrochloride
Glycyrrhetinic acid
