摘要
目的:研究葡萄籽原花青素对大鼠脑缺血再灌注损伤的保护作用。方法:采用尼龙线栓塞大鼠大脑中动脉制备大鼠局灶性脑缺血再灌注模型,观察不同剂量的葡萄籽原花青素对脑梗死面积、脑组织含水量及血清中肌酸激酶(CK)、乳酸脱氢酶(LDH)和超氧化物歧化酶(SOD)活性的影响。结果:葡萄籽原花青素3、15、30 mg·kg-1可显著减小脑缺血再灌注损伤大鼠的行为评分,减轻缺血侧脑半球水肿程度,缩小脑梗死面积,显著降低血清中CK、LDH的活性,明显升高血清中SOD的活性。结论:葡萄籽原花青素对大鼠脑缺血再灌注损伤有保护作用,其升高血清SOD活性作用可能是其保护作用的机制之一。
Objective: To study the protective effect of procyanidins (PC) on cerebral ischemia-reperfusion injury in rat. Method: The rat model of cerebral ischemia-reperfusion injury was established by middle cerebral artery occlusion (MCAO) with nylon suture. CK, LDH, and SOD in serum were determined. Result: In rat model of cerebral ischemia-reperfusion injury, PC 3,15,30 mg·kg-1 markedly decreased neurological deficit score, cerebral edema, and infarction area, significantly reduced activity of CK, LDH in serum , enhanced activity of SOD in serum. Conclusion: PC have a protective effect on cerebral ischemia-reperfusion injury in rat, its effect of enhancing activity of SOD in serum may be one of its protective mechanism.
出处
《中国药师》
CAS
2005年第7期541-542,共2页
China Pharmacist
关键词
原花青素
脑缺血
再灌注损伤
抗氧化
Procyanidins
Cerebral ischemia
Reperfusion injury
Anti-oxidation
