摘要
目的与方法 以对甲氧基苯甲醛为原料,醋酸铵为催化剂,经Knoevenagel反应,采用微波辐射技术合成了中间体对甲氧基肉桂酸,再以对甲苯磺酸为催化剂,经酯化反应得对甲氧基肉桂酸乙酯。结果与结论两步反应的产率分别为87. 8%和91. 0%,产品结构经IR和1H NMR(CDCl)确证。
An efficient synthesis of p-methoxy cinnamic acid, a key intermediate for ethyl p-methoxy cinnamate, was developed on the basis of Knoevenagel condensation of p-anisaldehyde with a catalytic amount of ammonium acetate under microwave irradiation in the yield of 87.8%. Then, p-methoxy cinnamic acid obtained was converted to ethyl p-methoxy cinnamate by esterification using p-toluenesulfonic acid as catalyst in excellent yield (91.0%). The structures of p-methoxy cinnamic acid and ethyl p-methoxy cinnamate were confirmed by IR and ~1H-NMR.
出处
《广东药学院学报》
CAS
2005年第2期117-119,共3页
Academic Journal of Guangdong College of Pharmacy
