摘要
生物降解材料聚(乳酸-乙醇酸) (PLGA)具有良好的生物相容性,在药物缓释材料、组织工程材料、手术缝合线等医用领域有广泛的应用。综述了PLGA的合成、性能与应用,尤其是详细介绍了PLGA类生物降解高分子的合成研究进展,指出简单易行的以乳酸。
Biodegradable material poly (lactic acid-glycolic acid, PLGA) has good biocompatibility and extensive application in the medicine fields such as drug delivery material, tissue engineering scaffold and surgical suture. The synthesis, properties and application of PLGA are reviewed in this paper, especially the research progress on the synthesis are introduced in detail. The future study of PLGA should be emphasized on reduce of the synthetic cost, and for this purpose the simple and practicable direct polycondensation method using lactic acid(LC) and glycolic acid(GA) as starting monomers should be paid more attention.
出处
《江苏化工》
2005年第2期9-12,25,共5页
Jiangsu Chemical Industry
基金
广东省自然科学基金资助项目(020885)
关键词
生物降解材料
聚(乳酸-乙醇酸)(PLGA)
共聚物
合成
开环聚合
直接缩聚
biodegradable material
poly(lactic acid-glycolic acid, PLGA)
copolymer
synthesis
ring-opening polymerization
direct polycondensation
