摘要
目的 探讨脑膜癌病的临床和脑脊液细胞学特征。方法 回顾性分析44例确诊为脑膜癌病患者的临床、影像学及脑脊液资料。结果 本组临床表现为头痛、背痛31例,脑神经损害18例,脑膜刺激征25例。头颅MRI增强扫描显示软脑膜弥漫性异常增强3例。脑脊液压力增高32例,细胞数增多41例,以激活型单核细胞和淋巴细胞为主; 44例脑脊液细胞学检查均发现肿瘤细胞, 5例为颅内原发肿瘤,其余39例颅外转移肿瘤细胞学分类为腺癌33例、恶性淋巴瘤3例、小细胞未分化癌2例及鳞癌1例。结论 脑膜癌病的临床表现及影像学检查缺乏特异性,脑脊液细胞学检查是诊断脑膜癌病的可靠依据。
Objective To explore clinical and cytological features of CSF in meningeal carcinomatosis.Methods The data of clinic, imaging, and cerebrospinal fluid in 44 cases with meningeal carcinomatosis were analyzed retrospectively.Results 31 cases appeared headache or notalgia, 18 cases had cranial nerve lesions, 25 cases showed meningeal irritation sign. MRI enhancement scanning found abnormally diffused piamater enhancement in 3 cases. Cerebrospinal fluid pressure of 32 cases increased, cell population of CSF increased in 41 cases and the most cells were activated monocytes and lymphocytes. All the 44 cases found tumor cells in cytological examination of CSF. 5 cases were intracalvarial primartumors, and the others were metastatic tumors. Cytologic classification showed adenocarcinoma of 33 cases, malignant lymphoma of 3 cases, undifferentiated carcinoma of 2 cases and squamous cell carcinoma of 1 case. Conclusions The clinical manifestations and imaging results of meningeal carcinomatosis lack specificity, and cytological examination of CSF is a reliable diagnosing method for this disease.
出处
《临床神经病学杂志》
CAS
北大核心
2005年第2期111-113,共3页
Journal of Clinical Neurology
关键词
脑膜癌病
脑脊液
细胞学
meningeal carcinomatosis
cerebrospinal fluid
cytology
