摘要
目的 :优选骆驼蓬总碱片最佳处方。方法 :以辅料碳酸钙、吐温 -80、淀粉及润滑剂 (硬脂酸镁∶滑石粉 )用量为4因素 ,每因素取3水平 ,以总碱片中去氢骆驼蓬碱的体外溶出参数 (Td)为指标进行正交试验。结果 :辅料中影响去氢骆驼蓬碱Td 的主要因素为吐温 -80和碳酸钙用量 (P<0 .05) ;经试验筛选出的最佳处方为骆驼蓬总碱浸膏粉适量 (总碱10mg/片 )、淀粉45mg、吐温 -80用量1 %、硬脂酸镁0. 1mg、滑石粉0 .31mg、氧化镁适量 ;Td=25 .01min。结论 :筛选出的最佳处方具有辅料价廉易得、有效成分溶出快、制备简单、稳定等特点。
OBJECTIVE:To optimize the best formula of the total alkaloid tablets of peganum harmala.METHODS:3 levels from each of the amount of four factors-excipient calcium carbonate,tween-80,starch and emollient(magnesium stearate:french chalk) were subjected to the orthogonal design with the parameter of dissolution(Td) of the harmine in tablet as an index.RESULTS:The amount of tween-80 and calcium carbonate(P<0.05)are the main factors that had influence on the Td.The best selected formula was composed of quantum of the powered extract of the total alkaloid(10 mg/tablet),starch 45mg,tween-80 1%,Magnesium stearate 0.1mg,french chalk 0.31mg,and quantum of MgO;Td=25.01min. CONCLUSION:The selected formula is cheap and accessible in excipient,fast in effective constituents dissolution,simple in preparation,stable and etc.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第6期423-425,共3页
China Pharmacy
关键词
骆驼蓬
总生物碱片
处方组成
正交试验
Peganum harmala
Total alkaloid tablets
Formula
Orthogonal experiment
