摘要
对单克隆抗体Ｄ＿２（ＭｃＡｂＤ＿２）与环化ＤＴＰＡ酸酐（ＣＤＴＰＡＡ）偶联的方法和￣（９０）Ｙ标记单克隆抗体０２（ＭｃＡｂＤ＿２）的条件进行了研究，结果表明：在标记抗体￣（９０）Ｙ－ＤＴＰＡ－ＭｃＡｂＤ＿２（肺癌治疗药物）比活度为３．７×１０￣４Ｂｑ／μｇ时，标记率＞９０％。标记抗体￣（９０）Ｙ－ＤＴＰＡ－ＭｃＡｂＤ＿２放化纯度＞９８％，在体外有很好的稳定性，并且有７３％的免疫活性，可用于临床研究。
The coupling of monoclonal antitheies D_2(McAbD_2)to bicyclic DTPA anhydride(CDTPAA)and the methed of labeling monoclonal antibodies D_2 with￣(90) Y have been studied.The resuIts have showed that when McAbD_2 is labeled with￣(90) Y the specific activity of labeled antibodies is 3.7×10￣4 Bq/μg,the radiochemical purity is more than 98%,the labeling efficiency is more than 90%,and have a good stability in vitro and immunological activity of 73%.
出处
《同位素》
CAS
北大核心
1994年第1期21-24,共4页
Journal of Isotopes
关键词
抗癌药
肺肿瘤
标记化合物
钇90
bicyclic DTPA anhydride(CDTPAA)monoclonal antibodies D_2(McAbD_2)couple ￣(90)Y label immunological activity
