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心肌钠氢交换抑制药在心血管疾病治疗中的应用 被引量：1

Use of myocardial Na^+/H^+ exchanger inhibitor in treatment of cardiovascular disease
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摘要 心肌钠氢交换抑制药通过抑制心肌细胞内外钠氢交换,从而防止或减少心肌细胞内钙超负荷。研究表明心肌钠氢交换抑制药对心肌缺血、再灌注损伤、心肌肥厚和心力衰竭有明确的治疗作用。 Myocardial Na +/H + exchanger inhibitor may prevent or decrease myocardial intracellular calcium overload through inhibiting myocardial Na +/H + exchange. Myocardial Na +/H + exchanger inhibitor possesses obvious treating effect for myocardial ischemia, reperfusion injury, myocardial hypertrophy and heart failure. The results showed that myocardial Na +/H + exchanger inhibitor can offer benefit for the treatment of ischemia and postinfarction heart failure.
作者 黄震华
机构地区 上海第二医科大学附属第九人民医院心血管病研究室
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2005年第3期239-242,共4页 Chinese Journal of New Drugs and Clinical Remedies
关键词 心血管疾病 心肌缺血 心力衰竭 充血性 钠氢交换抑制药 阿米洛利 卡立泊来德 cardiovascular disease myocardial ischemia heart failure, congestive Na +/H + exchanger inhibitor amiloride cariporide
分类号 R972 [医药卫生—药品] R541 [医药卫生—心血管疾病]
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参考文献12

  • 1NUMATA M, PETRECCA K, LAKE N, et al. Identification of a mitochondrial Na^+/H^+ exchanger[J]. J Biol Chem, 1998, 273(12) :6951-6959.
  • 2KINSELLA JL, HELLER P, FROEHLICH JP. Na^+/H^+ exchanger: proton modifier site regulation of activity[J]. Biochem Cell Biol, 1998, 76(5): 743-749.
  • 3PETRECCA K, ATANASIU R, GRINSTEIN S, et al. Subcellular localization of the Na^+/H^ + exchanger NHE1 in rat myocardium [J]. Am J Physiol, 1999, 276(2 Pt 2) :H709-H717.
  • 4KARMAZYN M, SOSTARIC JV, GAN XT. The myocardial Na^ + /H^ + exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure[J]. Drugs, 2001,61 (3) :375-389.
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同被引文献5

  • 1Hearse D J.Reperfusion of the ischemic myocardium[J].J Mol Cel Cardiol,1977,9(8):605-616.
  • 2Putney L K,Denker S P,Barber D L.The changing face of the Na^+/H^+ exchanger,NHE1:structure,regulation,and cellular actions[J].Annu Rev Pharmacol Toxicol,2002,42(4):527-552.
  • 3Fliegel L.The Na+/H+ exchanger isoform 1[J].Int J Biochem Cell Biol,2005,37(1):33-37.
  • 4Bobulescu I A,Di Sole F,Mde O W.Na^+/H^+ exchangers:physiology and link to hypertension and organ ischemia[J].Curr Opin Nephrol Hypertens,2005,14(5):485-494.
  • 5Klein H H,Pich S,Bohle R M.Na^+/H^+ exchange inhibitor Cariporide attenuates cell injury predominantly during ischemia and not at onset of reperfusion in porcine hearts with low residual blood flow[J].Circulation,2000,102 (16):1977-1982.

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中国新药与临床杂志
2005年 第3期

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