摘要
染色质的结构和组成直接影响转录因子与基因启动子的结合,并最终导致基因的活化或沉默。多年来在酵母和动物等领域的研究已经证实,起关键调节作用的转录因子表达模式的建立和维持需要染色质重塑。外界和细胞内部信号介导的染色质重塑调控基因的表达,并最终调控细胞的分化和生物个体的发育。近几年人们发现高等植物也存在与动物和酵母同源的参与染色质重塑的蛋白质因子。最近的研究结果表明,决定高等植物开花时间关键基因的表达调控就是通过外界信号影响其染色质结构实现的。
The changes in conformational structure and composition of chromatin led to the activation orsilence of genes through mediating the combination between transcription factors and gene promoter directly. Thestudies in yeast and animal system had suggested that chromatin remodeling was required for the establishment andmaintenance of the expression pattern of the transcription factors, which played an important role in regulation ofgene expression. The environmental signals regulated gene expression and eventually controlled cell differentiationand individual development through chromatin remodeling regulation. The protein mediators involved in chromatinremodeling in yeast and animal system had also been found in higher plant. Recent studies indicated that externalsignals mediate chromatin conformational structure to regulate the expression of the key genes which control theflower time. This paper provided briefly summary the progresses in this field.
出处
《细胞生物学杂志》
CSCD
2005年第1期24-28,共5页
Chinese Journal of Cell Biology
基金
国家杰出青年科学基金(No.30025024)
教育部骨干教师基金和教育部优秀教师基金资助~~
