摘要
目的 探讨再生障碍性贫血 (再障 )患儿外周血淋巴细胞表型的变化 ,了解其在发病中的作用及临床意义。方法 将 1 1 5名确诊为再障的患儿取外周血作淋巴细胞表型分析并与正常组比较。结果 再障组CD4+ % ,CD8+ % ,CD4/CD8分别为 2 9.53± 8.94,34 .2 5± 1 0 .38,0 .96± 0 .53 ,对照组为 35 .2 5± 5 .1 6 ,2 5 .0 8± 4 .34 ,1 .48± 0 .46 ,两者比较有显著差异 (P <0 .0 0 5) ,而重型再障的细胞表型CD4/CD8、γδT细胞百分率、HLA DR +%则更高于慢性再障 ,两者有显著差异。CD3+ %两组分别为 69.53± 2 4 .35和 69.98± 5 .79,两者比较无显著差异 (P <0 .0 5)。结论 再障患儿存在严重的免疫异常 ,且与疾病严重程度呈正相关 ,临床可行免疫抑制治疗。
Objective To investigate the phenotypes and expression of activated T-cell membrane molecules on lymphocytes in the peripheral blood(PB) of children with aplastic anemia (AA) and find out its clinical significance.Methods The lymphocytes from PB of the 115 AA patients were analyzed by flow cytometry and compared with normal group.Results The expression of CD8+ increased and the expression of CD4+ decreased. The ratio of CD4/CD8 cells decreased ,and was more significant in the patients with serious AA(SAA). The expression of HLA-DR and γδT-cell also increased, and was more significant in SAA patients. The expression of CD3+ was not significantly changed.Conclusions There is significant immune abnormal in AA patients and more important in SAA patients. The immunosuppressant is useful in clinical treatment.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2005年第1期29-30,共2页
Journal of Applied Clinical Pediatrics
